4472-73-5

Upstream product

• 569-80-2 penduletin 
• 77-78-1 dimethyl sulfate 
• 29536-41-2 3,5,4'-trihydroxy-6,7-dimethoxy-flavone 
• 27782-63-4 5,7-Dihydroxy-3,6-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 794-94-5 p-Methoxybenzoic anhydride 
• 14639-73-7 1-(3,6-dihydroxy-2,4-dimethoxy-phenyl)-2-methoxy-ethanone 
• 100059-77-6 1-(2,6-dihydroxy-3,4-dimethoxy-phenyl)-2-methoxy-ethanone 
• 14787-34-9 5-hydroxy-3,4',6,7-tetramethoxyflavone 
• 111316-43-9 6-hydroxy-3,5,7-trimethoxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 2569-77-9 5,6,7,4'-tetra methoxyl-flavanone 
• 5867-71-0 3-hydroxy-5,6,7,4'-tetramethoxymethoxyflavone 

Downstream Products

• 22248-22-2 2-methoxy-1-(2,3,4,6-tetramethoxy-phenyl)-ethanone 
• 14787-34-9 5-hydroxy-3,4',6,7-tetramethoxyflavone 
• 14290-59-6 2-hydroxy-ω,4,5,6-tetramethoxyacetophenone 

Relevant academic research and scientific papers

FOUR 6-HYDROXYFLAVONOLS FROM BLUMEA MALCOLMII

Four new 6-hydroxyflavonols have been isolated from Blumea malcolmii and identified as 6-hydroxy-3,5,7,4'-tetramethoxyflavone, 6,2',5'-trihydroxy-3,5,7-trimethoxyflavone, 6,5'-dihydroxy-3,5,7,2'-tetramethoxyflavone and 6-hydroxy-3,5,7,2',5'-pentamethoxyfl

Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae)

A series of 16 flavonoids were isolated and prepared from bud exudate of Gardenia urvillei and Gardenia oudiepe, endemic to New Caledonia. Most of them are rare polymethoxylated flavones. Some of these compounds showed noticeable activity against Leishmania (Leishmania) amazonensis, Plasmodium falciparum and Trypanosoma brucei gambiense, in addition to tubulin polymerization inhibition at low micromolar concentration. We also provide a full set of NMR data as some of the flavones were incompletely described.

ANTIMICROBIAL FLAVONOIDS FROM PSIADIA TRINERVIA AND THEIR METHYLATED AND ACETYLATED DERIVATIVES

Key Word Index - Psiadia trinervia; Compositae; flavonoids; antifungal; antibacterial; Cladosporium cucumerinum; Bacillus cereus; bioautography.Abstract - From a dichloromethane extract and a hydrolysed methanolic extract from the leaves of Psiadia trinervia, 13 3-methylated flavonol have beeen isolated.Their structures were established by the usual spectoscopic methods (UV, EIMS, 1H and 13CNMR).Ayanin, casticin, chrysosplenol-D and 5,7,4'-trihydroxy-3,8-dimethoxyflavone were responsible for the antifungal activity found in the preliminary screening.Chrysosplenol-D, isokaemferide, 5,7,4'-trihydroxy-3,3'-dimethoxyflavone and 5,7,4'-trihydroxy-3,8-dimethoxyflavone displayed antibacterial activity.Twenty-nine derivatives were prepared by permethylation and selective methylation of the free hydroxyl group at C-5.The antimicrobial activities of the isolates and derivatives were determined by bioautographic assays using C. cucumerinum and B. cereus as test organisms.

STRUCTURAL ELUCIDATION OF POLYMETHOXYFLAVONES FROM SHIFT REAGENT PROTON NMR MEASUREMENTS

Key Word Index - Polymethoxyflavones; 1H NMR; shift reagents; Pr(fod)3; structural elucidation. The quantitative shift reagent behavior of polymethoxylated flavones in the presence of Pr(fod)3 shows that for structural elucidation of these molecules the degree of substitution on the neighbourhood of the carbonyl group can be determined from the number of signals that are strongly shifted and broadened.The induced shifts of the remaining signals are of complementary help and even the resonances of individual methoxy groups can be ascribed.