8-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a][1,3,5]triazine-2,4(1H,3H)-dione

Base Information

Chemical Name:8-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a][1,3,5]triazine-2,4(1H,3H)-dione
CAS No.:1313530-18-5
Molecular Formula:C₂₂H₂₀N₆O₅
Molecular Weight:448.438
Hs Code.:

Synonyms:8-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a][1,3,5]triazine-2,4(1H,3H)-dione

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Chemical Property of 8-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a][1,3,5]triazine-2,4(1H,3H)-dione

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Technology Process of 8-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a][1,3,5]triazine-2,4(1H,3H)-dione

There total 8 articles about 8-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a][1,3,5]triazine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1313529-93-9
5-amino-4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazole

: 27738-96-1
chlorocarbonyl isocyanate

: 1313530-18-5
8-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a][1,3,5]triazine-2,4(1H,3H)-dione

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tet.2011.04.077

Reference yield:

: 271-63-6
7-Azaindole

: 1313530-18-5
8-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a][1,3,5]triazine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / ethanol; water / 0.5 h / 0 °C

1.2: 18 h / 100 °C

1.3: 20 °C / pH 11

2.1: acetic acid / water; N,N-dimethyl-formamide / 8 h / 110 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

3.2: 0 - 20 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: hydrogenchloride; hydrazine hydrate / ethanol / 20 h / Reflux

6.1: triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; sodium hydride; hydrazine hydrate; acetic acid; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 1.1: Mannich reaction / 1.2: Mannich reaction;
DOI:10.1016/j.tet.2011.04.077

Reference yield:

: 1313530-14-1
2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-oxo-3-(3,4,5-trimethoxyphenyl)propanenitrile

: 1313530-18-5
8-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a][1,3,5]triazine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; hydrazine hydrate / ethanol / 20 h / Reflux

2: triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; hydrazine hydrate; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2011.04.077