Technology Process of 4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,3,5,6-tetrafluorobenzyl phosphoramide
There total 5 articles about 4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,3,5,6-tetrafluorobenzyl phosphoramide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C11H15F3N2O6;
With
AlH2LiSe;
In
tetrahydrofuran;
at 5 ℃;
for 0.583333h;
Inert atmosphere;
4-azido-2,3,5,6-tetrafluorobenzyl phosphoramide mustard;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
Inert atmosphere;
DOI:10.1016/j.bmc.2016.04.035
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-methylcyclohexylamine; triethylamine / tetrahydrofuran; toluene / 0.5 h / -15 - -10 °C
2.1: AlH2LiSe / tetrahydrofuran / 0.58 h / 5 °C / Inert atmosphere
2.2: 24 h / 20 °C / Inert atmosphere
With
N-methylcyclohexylamine; AlH2LiSe; triethylamine;
In
tetrahydrofuran; toluene;
DOI:10.1016/j.bmc.2016.04.035
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid; sodium nitrite / water / 0.67 h / 0 °C
1.2: 1 h / 20 °C
2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 1 h / 20 °C
2.2: 2 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.33 h / -78 °C
3.2: 5 h / -78 °C
4.1: ammonia / 0.17 h
5.1: AlH2LiSe / tetrahydrofuran / 0.58 h / 5 °C / Inert atmosphere
5.2: 24 h / 20 °C / Inert atmosphere
With
n-butyllithium; sulfuric acid; AlH2LiSe; ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium nitrite;
In
tetrahydrofuran; cyclohexane; water;
DOI:10.1016/j.bmc.2016.04.035
