4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,3,5,6-tetrafluorobenzyl phosphoramide

Base Information

Chemical Name:4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,3,5,6-tetrafluorobenzyl phosphoramide
CAS No.:1028745-53-0
Molecular Formula:C₁₈H₂₁Cl₂F₇N₅O₅P
Molecular Weight:622.264
Hs Code.:

Synonyms:4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,3,5,6-tetrafluorobenzyl phosphoramide

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Chemical Property of 4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,3,5,6-tetrafluorobenzyl phosphoramide

Chemical Property:

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Technology Process of 4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,3,5,6-tetrafluorobenzyl phosphoramide

There total 5 articles about 4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,3,5,6-tetrafluorobenzyl phosphoramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1028745-31-4
4-azido-2,3,5,6-tetrafluorobenzyl phosphoramide mustard

: C₁₁H₁₅F₃N₂O₆

: 1028745-53-0
4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,3,5,6-tetrafluorobenzyl phosphoramide

Guidance literature:: C₁₁H₁₅F₃N₂O₆; With AlH₂LiSe; In tetrahydrofuran; at 5 ℃; for 0.583333h; Inert atmosphere;

4-azido-2,3,5,6-tetrafluorobenzyl phosphoramide mustard; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmc.2016.04.035

Reference yield:

: 2419-34-3
N^α-trifluoroacetyl glutamine

: 1028745-53-0
4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,3,5,6-tetrafluorobenzyl phosphoramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-methylcyclohexylamine; triethylamine / tetrahydrofuran; toluene / 0.5 h / -15 - -10 °C

2.1: AlH₂LiSe / tetrahydrofuran / 0.58 h / 5 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

With N-methylcyclohexylamine; AlH₂LiSe; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmc.2016.04.035

Reference yield:

: 944-43-4
4-amino-2,3,5,6-tetrafluorobenzoic acid

: 1028745-53-0
4-(Nα-trifluoroacetyl-L-glutaminyl)amido-2,3,5,6-tetrafluorobenzyl phosphoramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; sodium nitrite / water / 0.67 h / 0 °C

1.2: 1 h / 20 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 1 h / 20 °C

2.2: 2 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.33 h / -78 °C

3.2: 5 h / -78 °C

4.1: ammonia / 0.17 h

5.1: AlH₂LiSe / tetrahydrofuran / 0.58 h / 5 °C / Inert atmosphere

5.2: 24 h / 20 °C / Inert atmosphere

With n-butyllithium; sulfuric acid; AlH₂LiSe; ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium nitrite; In tetrahydrofuran; cyclohexane; water;
DOI:10.1016/j.bmc.2016.04.035