944-43-4

Usage

Uses

It is used in chemical research and as pharmaceutical intermediate.

InChI:InChI=1/C7H3F4NO2/c8-2-1(7(13)14)3(9)5(11)6(12)4(2)10/h12H2,(H,13,14)

Upstream product

• 1548-74-9 4-amino-2,3,5,6-tetrafluorobenzamide 
• 122590-77-6 4-azido-2,3,5,6-tetrafluorobenzoic acid 
• 1208262-30-9 potassium 4-amino-2,3,5,6-tetrafluorobenzoate 
• 950-68-5 ethyl-2,3,5,6-tetrafluoro-4-amino-benzoate 
• 652-31-3 2,3,4,5,6-pentafluorobenzamide 
• 124-38-9 carbon dioxide 
• 700-17-4 2,3,5,6-tetrafluoroaniline 

Downstream Products

• 138724-37-5 Methyl 3-(4-Amino-2,3,5,6-tetrafluorobenzamido)benzoate 
• 122590-77-6 4-azido-2,3,5,6-tetrafluorobenzoic acid 
• 146698-38-6 2,3,5,6-tetrafluoro-4-sulfinylaminobenzoyl chloride 
• 5211-47-2 2,3,5,6-tetrafluoro-4-nitroso-benzoic acid 
• 873536-93-7 2,3,5,6-tetrafluoro-4-iodo-benzoic acid 
• 837368-26-0 2,3,5,6-tetrafluoro-4-iodo-benzaldehyde 
• 146698-35-3 diethyl N-(4-amino-2,3,5,6-tetrafluorobenzoyl)-L-glutamate 
• 146698-36-4 diethyl N-<4-(prop-2-ynylamino)-2,3,5,6-tetrafluorobenzoyl>-L-glutamate 
• 146698-37-5 diethyl N-<4--N-prop-2-ynylamino>-2,3,5,6-tetrafluorobenzoyl>-L-glutamate 
• 122590-78-7 4-Azido-2,3,5,6-tetrafluorobenzoyl Chloride 
• 131589-59-8 3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene 
• 133295-95-1 3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene 
• 5211-50-7 2,3,5,6-tetrafluoro-4-(2-oxa-3-aza-bicyclo[2.2.2]oct-5-en-3-yl)-benzoic acid 
• 950-68-5 ethyl-2,3,5,6-tetrafluoro-4-amino-benzoate 

Relevant academic research and scientific papers

Extending the series of p-substituted tetrafluorobenzoic acids: synthesis, properties and structure

The synthesis of the derivatives of p-aminotetrafluorobenzoic acid, p-H2NC6F4CO2H (2b), by hydrolysis, acylation or interaction with aldehydes was developed giving H2NC6F4CO2K (2a), C6F5C(O)N(H)C6F4CO2Et (3) and (E)-ArCH[dbnd]NC6F4CO2Et (4–11). The chemical derivatization of tetrafluoroterephthalic acid, p-HO2CC6F4CO2H (12), by hydrolysis, etherification and reduction was performed giving a number of symmetrical X(O)CC6F4C(O)X (13–15; X?=?Cl, NEt2, OMe) or unsymmetrical YC6F4CO2Me (15a–b, 16, 18–21; Y?=?CO2K, CO2H, CH2OH, C(O)Cl, C(O)C6H3(i-Pr)2, CO2CH2C6F4CO2Me, CO2C6H4Bu-t), HOCH2C6F4CO2H (17), [MeO2CC6F4]2Y (22, 23; Y?=?OCH2CH2O, N(H)C6H4N(H)) compounds. All substances were thoroughly investigated by spectroscopic methods (multinuclear NMR and IR spectroscopy, mass-spectrometry). The molecular structures of p-H2NC6F4CO2Et (2) and p-HO2CC6F4CO2Me (15b) have been determined by X-ray diffraction analysis.

Synthesis of bitriazolyl nucleosides and unexpectedly different reactivity of azidotriazole nucleoside isomers in the Huisgen reaction

Novel bitriazolyl nucleosides were synthesized via the Huisgen reaction, starting with 3-azidotriazole nucleoside (1). Surprisingly, its isomer, 5-azidotriazole nucleoside (1′) did not yield the corresponding Huisgen reaction products efficiently because it was rapidly reduced to amine in the presence of Cu(ii)-ascorbate. The significant differences between the reactivity of these two isomers in Cu(ii)-ascorbate mediated reactions are mainly due to differences in their electronic properties and steric congestion as a result of different relative positions of the azido and the ribosyl moieties. This journal is The Royal Society of Chemistry.