4-(1-methylhydrazino)-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

Base Information

Chemical Name:4-(1-methylhydrazino)-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine
CAS No.:109890-55-3
Molecular Formula:C₁₆H₁₄F₃N₅S
Molecular Weight:365.382
Hs Code.:

Synonyms:4-(1-methylhydrazino)-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

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Chemical Property of 4-(1-methylhydrazino)-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

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Technology Process of 4-(1-methylhydrazino)-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

There total 4 articles about 4-(1-methylhydrazino)-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 109890-47-3
4-methylthio-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

: 60-34-4
methylhydrazine

: 109890-55-3
4-(1-methylhydrazino)-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

Guidance literature:: In pyridine; at 50 ℃; for 20h;
DOI:10.1021/jm00394a038

Reference yield:

: 109890-44-0
2-amino-6-<<3-(trifluoromethyl)phenyl>thio>-4(3H)-quinazolinone

: 109890-55-3
4-(1-methylhydrazino)-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / P₂S₅ / pyridine / 22 h / 80 °C

2: 53 percent / dimethylformamide / 1 h / Ambient temperature

3: 30 percent / pyridine / 20 h / 50 °C

With tetraphosphorus decasulfide; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a038

Reference yield:

: 51123-99-0
6-<<3-(trifluoromethyl)phenyl>thio>-2,4-quinazolinediamine

: 109890-55-3
4-(1-methylhydrazino)-6-<<3-(trifluoromethyl)phenyl>thio>-2-quinazolinamine

Guidance literature:: Multi-step reaction with 4 steps

1: 92.7 percent / 2 N aq. HCl / bis-(2-methoxy-ethyl) ether / 6 h / Heating

2: 70 percent / P₂S₅ / pyridine / 22 h / 80 °C

3: 53 percent / dimethylformamide / 1 h / Ambient temperature

4: 30 percent / pyridine / 20 h / 50 °C

With hydrogenchloride; tetraphosphorus decasulfide; In pyridine; diethylene glycol dimethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a038