Dimethyl 4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:Dimethyl 4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:56820-27-0
Molecular Formula:C15H14ClNO4
Molecular Weight:307.733
Hs Code.:
NSC Number:173327
DSSTox Substance ID:DTXSID10306025
Nikkaji Number:J1.809.836I
ChEMBL ID:CHEMBL1324955

Synonyms:dimethyl 4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;56820-27-0;NSC173327;MLS000062024;CHEMBL1324955;DTXSID10306025;OXIGQRYDADOYEB-UHFFFAOYSA-N;HMS2330E12;HMS3536D05;STK084317;AKOS000663135;NSC-173327;4-(2-Chloro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester;SMR000070947;SR-01000585213;SR-01000585213-1;Dimethyl 4-(2-chlorophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate;Dimethyl 4-(2-chlorophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate #;3,5-DIMETHYL 4-(2-CHLOROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE

Suppliers and Price of Dimethyl 4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of Dimethyl 4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Vapor Pressure:3.02E-07mmHg at 25°C
Boiling Point:419.5°Cat760mmHg
Flash Point:207.5°C
Density:1.301g/cm³
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:307.0611356
Heavy Atom Count:21
Complexity:454

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CNC=C(C1C2=CC=CC=C2Cl)C(=O)OC

Technology Process of Dimethyl 4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

There total 6 articles about Dimethyl 4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 496788-77-3
1-benzhydryl-4-(2-chlorophenyl)-3,5-bis(methoxycarbonyl)-1,4-dihydropyridine

: 56820-27-0
4-(2-chlorophenyl)-3,5-bis(methoxycarbonyl)-1,4-dihydropyridine

Guidance literature:: With aluminium trichloride; In benzene; at 60 ℃; for 6h;
DOI:10.1016/S0040-4020(02)00941-9

Reference yield: 81.0%

: 89-98-5
2-chloro-benzaldehyde

: 922-67-8
propynoic acid methyl ester

: 56820-27-0
4-(2-chlorophenyl)-3,5-bis(methoxycarbonyl)-1,4-dihydropyridine

Guidance literature:: With 1?(1?carboxymethyl)?3?methylimidazolium tetrafluoroborate; ammonium carbonate; In neat (no solvent); at 60 ℃; for 0.166667h; Sonication; Green chemistry;
DOI:10.1016/j.ultsonch.2014.05.026

Reference yield:

: 93-60-7
methyl 3-pyridinecarboxylate

: 56820-27-0
4-(2-chlorophenyl)-3,5-bis(methoxycarbonyl)-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / acetone / 264 h / 20 °C

2.1: CuI / tetrahydrofuran / -78 - 20 °C

2.2: tetrahydrofuran / 3 h / -40 - 20 °C

2.3: 45 percent / tetrahydrofuran / 20 °C

3.1: 80 percent / methanol / 0.02 h / 20 °C

4.1: 98 percent / AlCl₃ / benzene / 6 h / 60 °C

With copper(l) iodide; aluminium trichloride; In tetrahydrofuran; methanol; acetone; benzene;
DOI:10.1016/S0040-4020(02)00941-9