1-Ethyl-4-oxo-7-(2-phenyl-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

Base Information

Chemical Name:1-Ethyl-4-oxo-7-(2-phenyl-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid
CAS No.:134812-22-9
Molecular Formula:C₂₁H₁₆N₂O₃S
Molecular Weight:376.436
Hs Code.:

Synonyms:1-Ethyl-4-oxo-7-(2-phenyl-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

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Chemical Property of 1-Ethyl-4-oxo-7-(2-phenyl-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

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Technology Process of 1-Ethyl-4-oxo-7-(2-phenyl-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

There total 23 articles about 1-Ethyl-4-oxo-7-(2-phenyl-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 134812-15-0
7-(bromoacetyl)-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

: 2227-79-4
benzenecarbothioamide

: 134812-22-9
1-Ethyl-4-oxo-7-(2-phenyl-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃;
DOI:10.1002/jhet.5570280323

Reference yield:

: 99-03-6
1-(3-aminophenyl)ethanone

: 134812-22-9
1-Ethyl-4-oxo-7-(2-phenyl-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / Ac₂O / 48 h / Ambient temperature

2: 80 percent / Br₂ / CHCl₃ / 0.5 h / Heating

3: 89 percent / ethanol / 2 h / 50 °C

4: 1 h / 110 °C

5: diphenyl ether / 0.5 h / 250 °C

6: NaH / dimethylformamide / 4 h / 80 °C

7: conc. HCl/AcOH (50/50) / 3 h / Heating

With hydrogenchloride; bromine; acetic anhydride; sodium hydride; acetic acid; In diphenylether; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570280323

Reference yield:

: 56915-87-8
3-trifluoroacetamidoacetophenone

: 134812-22-9
1-Ethyl-4-oxo-7-(2-phenyl-thiazol-4-yl)-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1: p-CH₃C₆H₄SO₃H*H₂O / toluene / Heating

2: 72 percent / 10percent aq. NaOH / ethanol / Heating

3: toluene / Heating

4: 60 percent / diphenyl ether / Heating

5: 94 percent / K₂CO₃ / dimethylformamide / Heating

6: 87 percent / 1 N aq. NaOH / Heating

7: 96 percent / conc. HCl / Heating

8: 95 percent / gl. acetic acid, C₅H₅N*HBr₃ / Heating

9: 90 percent / dimethylformamide / 100 °C

With hydrogenchloride; sodium hydroxide; potassium carbonate; toluene-4-sulfonic acid; acetic acid; pyridinium hydrobromide perbromide; In diphenylether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jhet.5570280323