2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl trifluoromethanesulfonate

Base Information

• Chemical Name: 2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl trifluoromethanesulfonate
• CAS No.: 1198616-94-2
• Molecular Formula: C₄₁H₅₀F₃O₄PS
• Molecular Weight: 726.881
• Mol file: 1198616-94-2.mol

Synonyms:2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl trifluoromethanesulfonate

Chemical Property of 2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl trifluoromethanesulfonate

There total 4 articles about 2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

bis(3,5-di(tert-butyl)phenyl)phosphine oxide (325773-65-7) + 2,2'-bis-<<(trifluoromethyl)sulfonyl>oxy>biphenyl (17763-95-0) → 2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl trifluoromethanesulfonate (1198616-94-2)

Guidance literature:

With palladium diacetate; N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; In dimethyl sulfoxide; at 100 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.tet.2009.09.053

Reference yield: 51.0%

trifluoromethylsulfonic anhydride (358-23-6) + 2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-ol (1266398-33-7) → 2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl trifluoromethanesulfonate (1198616-94-2)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 ℃; Reflux;

DOI:10.1007/s11426-010-4172-z

Reference yield:

p-chlorodibenzo[c.e][1,2]oxaphosphorine (22749-43-5) → 2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl trifluoromethanesulfonate (1198616-94-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: iodine; magnesium / 2 h / 50 °C / Inert atmosphere; Reflux

1.2: 25 °C / Inert atmosphere; Reflux

1.3: 0 °C / Inert atmosphere

2.1: dihydrogen peroxide / dichloromethane; water / 0 - 20 °C

3.1: pyridine; dmap / dichloromethane / 0 °C / Reflux

With pyridine; dmap; dihydrogen peroxide; iodine; magnesium; In dichloromethane; water;

DOI:10.1007/s11426-010-4172-z

upstream raw materials:

bis(3,5-di(tert-butyl)phenyl)phosphine oxide

2,2'-bis-<<(trifluoromethyl)sulfonyl>oxy>biphenyl

p-chlorodibenzo[c.e][1,2]oxaphosphorine

trifluoromethylsulfonic anhydride

Downstream raw materials:

(S)-2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide