(S)-2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide

Base Information

Chemical Name:(S)-2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide
CAS No.:1198617-01-4
Molecular Formula:C₄₉H₆₀NO₃P
Molecular Weight:741.994
Hs Code.:

Synonyms:(S)-2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide

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Chemical Property of (S)-2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide

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Technology Process of (S)-2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide

There total 5 articles about (S)-2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1198616-97-5
C₄₂H₅₃O₃P

: 20989-17-7
(2S)-2-phenylglycinol

: 1198617-01-4
(S)-2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide

Guidance literature:: (2S)-2-phenylglycinol; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

C₄₂H₅₃O₃P; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.tet.2009.09.053

Reference yield: 56.0%

: 201230-82-2
carbon monoxide

: 1198616-94-2
2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl trifluoromethanesulfonate

: 20989-17-7
(2S)-2-phenylglycinol

: 1198617-01-4
(S)-2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 110 ℃; for 18h; optical yield given as %de;
DOI:10.1007/s11426-010-4172-z

Reference yield:

: 22749-43-5
p-chlorodibenzo[c.e][1,2]oxaphosphorine

: 1198617-01-4
(S)-2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine; magnesium / 2 h / 50 °C / Inert atmosphere; Reflux

1.2: 25 °C / Inert atmosphere; Reflux

1.3: 0 °C / Inert atmosphere

2.1: dihydrogen peroxide / dichloromethane; water / 0 - 20 °C

3.1: pyridine; dmap / dichloromethane / 0 °C / Reflux

4.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 110 °C

With pyridine; dmap; 1,3-bis-(diphenylphosphino)propane; dihydrogen peroxide; iodine; palladium diacetate; magnesium; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; dimethyl sulfoxide;
DOI:10.1007/s11426-010-4172-z