Buciclovir

Base Information

• Chemical Name: Buciclovir
• CAS No.: 86304-28-1
• Molecular Formula: C₉H₁₃N₅O₃
• Molecular Weight: 239.234
• Mol file: 86304-28-1.mol

Synonyms:

Chemical Property of Buciclovir

Chemical Property:

• Vapor Pressure: 1.37E-18mmHg at 25°C
• Boiling Point: 665°C at 760 mmHg
• Flash Point: 356°C
• PSA: 130.05000
• Density: 1.78g/cm³
• LogP: -0.97370

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Buciclovir

There total 4 articles about Buciclovir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(R)-4-(2-amino-6-(benzyloxy)-9H-purin-9-yl)butane-1,2-diol → (R)-9-(3,4-dihydroxybutyl)guanine (86304-28-1)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; methanol; at 20 ℃; for 18h;

DOI:10.1021/acs.joc.8b02442

Reference yield:

2-Amino-6-benzyloxypurine (19916-73-5) → (R)-9-(3,4-dihydroxybutyl)guanine (86304-28-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: potassium carbonate; hydroquinidine (anthraquinone-1,4-diyl) diether; potassium osmate; potassium hexacyanoferrate(III); methanesulfonamide / water; tert-butyl alcohol / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran; N,N-dimethyl-formamide / 12 h / 0 - 20 °C

4: hydrogenchloride / methanol; tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; potassium osmate; methanesulfonamide; tetrabutyl ammonium fluoride; potassium carbonate; hydroquinidine (anthraquinone-1,4-diyl) diether; potassium hexacyanoferrate(III); In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1021/acs.joc.8b02442

Reference yield:

6-(benzyloxy)-9-(3-(triethylsilyl)but-3-en-1-yl)-9H-purin-2-amine → (R)-9-(3,4-dihydroxybutyl)guanine (86304-28-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; hydroquinidine (anthraquinone-1,4-diyl) diether; potassium osmate; potassium hexacyanoferrate(III); methanesulfonamide / water; tert-butyl alcohol / 0 - 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran; N,N-dimethyl-formamide / 12 h / 0 - 20 °C

3: hydrogenchloride / methanol; tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; potassium osmate; methanesulfonamide; tetrabutyl ammonium fluoride; potassium carbonate; hydroquinidine (anthraquinone-1,4-diyl) diether; potassium hexacyanoferrate(III); In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1021/acs.joc.8b02442

upstream raw materials:

2-Amino-6-benzyloxypurine