5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-7-(5-(1-phenylethoxy)pyridin-3-yl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

Base Information

Chemical Name:5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-7-(5-(1-phenylethoxy)pyridin-3-yl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride
CAS No.:1610518-12-1
Molecular Formula:C₂₇H₃₀N₄O₄S₂*ClH
Molecular Weight:575.153
Hs Code.:

Synonyms:5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-7-(5-(1-phenylethoxy)pyridin-3-yl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

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Chemical Property of 5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-7-(5-(1-phenylethoxy)pyridin-3-yl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

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Technology Process of 5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-7-(5-(1-phenylethoxy)pyridin-3-yl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

There total 8 articles about 5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-7-(5-(1-phenylethoxy)pyridin-3-yl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.56%

: 1610520-30-3
(5-(1-phenylethoxy)pyridin-3-yl)boronic acid

: 1610520-84-7
(R)-7-bromo-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one

: 1610518-12-1
5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-7-(5-(1-phenylethoxy)pyridin-3-yl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

Guidance literature:: (5-(1-phenylethoxy)pyridin-3-yl)boronic acid; (R)-7-bromo-5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.333333h; Microwave irradiation;

With hydrogenchloride; In diethyl ether; ethyl acetate;

Reference yield:

: 28948-60-9
2-bromothieno[3,2-c]pyridin-4(5H)-one

: 1610518-12-1
5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-7-(5-(1-phenylethoxy)pyridin-3-yl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - -60 °C / Inert atmosphere

1.2: 1 h / -60 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

3.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

3.2: 20 °C

4.1: acetic acid / methanol / 0.25 h / 20 °C

4.2: 1 h / 50 °C

5.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 0.33 h / 120 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; n-butyllithium; potassium carbonate; caesium carbonate; acetic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; water;

Reference yield:

: 74115-13-2
5-bromopyridine-3-ol

: 1610518-12-1
5-methyl-2-((4-(methylsulphonyl)piperazin-1-yl)methyl)-7-(5-(1-phenylethoxy)pyridin-3-yl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C

1.2: 2 h / 60 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.5 h / 110 °C / Microwave irradiation

3.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 0.33 h / 120 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;