N-[3-benzoyl-4-(trifluoroacetylamino)phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide

Base Information

• Chemical Name: N-[3-benzoyl-4-(trifluoroacetylamino)phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide
• CAS No.: 366456-88-4
• Molecular Formula: C₄₂H₃₈F₃N₃O₅S
• Molecular Weight: 753.842

Synonyms:N-[3-benzoyl-4-(trifluoroacetylamino)phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide

Chemical Property of N-[3-benzoyl-4-(trifluoroacetylamino)phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide

Chemical Property:

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Technology Process of N-[3-benzoyl-4-(trifluoroacetylamino)phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide

There total 3 articles about N-[3-benzoyl-4-(trifluoroacetylamino)phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyloxycarbonyl-S-trityl-L-cysteine (21947-98-8,87494-13-1) → N-[3-benzoyl-4-(trifluoroacetylamino)phenyl]-Nα-tert-butyloxycarbonyl-S-tritylcysteinamide (366456-88-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / dimethylformamide / 0.08 h / -15 °C

2: dimethylformamide / -15 - 20 °C

With 4-methyl-morpholine; In N,N-dimethyl-formamide;

DOI:10.1021/jm010872r

Reference yield:

2-amino-5-nitrobenzophenone (1775-95-7) → N-[3-benzoyl-4-(trifluoroacetylamino)phenyl]-Nα-tert-butyloxycarbonyl-S-tritylcysteinamide (366456-88-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / pyridine / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 95 percent / SnCl₂*2H₂O / ethyl acetate / 2 h / Heating

3: dimethylformamide / -15 - 20 °C

With pyridine; tin(ll) chloride; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm010872r

Reference yield:

N-(2-benzoyl-4-nitrophenyl)trifluoroacetamide (313499-48-8) → N-[3-benzoyl-4-(trifluoroacetylamino)phenyl]-Nα-tert-butyloxycarbonyl-S-tritylcysteinamide (366456-88-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / SnCl₂*2H₂O / ethyl acetate / 2 h / Heating

2: dimethylformamide / -15 - 20 °C

With tin(ll) chloride; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm010872r

upstream raw materials:

N-tert-butyloxycarbonyl-S-trityl-L-cysteine

2-amino-5-nitrobenzophenone

N-(2-benzoyl-4-nitrophenyl)trifluoroacetamide

Downstream raw materials:

N-[3-benzoyl-4-[2-(4-nitrophenyl)acetylamino]phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide

N-[3-benzoyl-4-(4-methylphenylmethansulfonylamino)phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide

N-[3-benzoyl-4-(phenylmethansulfonylamino)phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide

N-[4-amino-3-benzoylphenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide

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