S-ethyl α-(4-isobutylphenyl)-α-(ethylsulfanyl)thiopropionate

Base Information

• Chemical Name: S-ethyl α-(4-isobutylphenyl)-α-(ethylsulfanyl)thiopropionate
• CAS No.: 467225-75-8
• Molecular Formula: C₁₇H₂₆OS₂
• Molecular Weight: 310.525
• Mol file: 467225-75-8.mol

Synonyms:S-ethyl α-(4-isobutylphenyl)-α-(ethylsulfanyl)thiopropionate

Chemical Property of S-ethyl α-(4-isobutylphenyl)-α-(ethylsulfanyl)thiopropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-ethyl α-(4-isobutylphenyl)-α-(ethylsulfanyl)thiopropionate

There total 3 articles about S-ethyl α-(4-isobutylphenyl)-α-(ethylsulfanyl)thiopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

dimethyl sulfate (77-78-1) + S-ethyl bis(ethylsulfanyl)(4-isobutylphenyl)thioacetate (467225-71-4) → S-ethyl α-(4-isobutylphenyl)-α-(ethylsulfanyl)thiopropionate (467225-75-8)

Guidance literature:

S-ethyl bis(ethylsulfanyl)(4-isobutylphenyl)thioacetate; With potassium tert-butylate; In tetrahydrofuran; at 20 - 25 ℃; for 0.166667h;

dimethyl sulfate; In tetrahydrofuran; at 20 - 25 ℃; for 0.5h;

DOI:10.1055/s-2002-28521

Reference yield:

methyl 4-iso-butylbenzoate (154320-56-6) → S-ethyl α-(4-isobutylphenyl)-α-(ethylsulfanyl)thiopropionate (467225-75-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran; hexane / 2 h / -95 °C

1.2: 94 percent / tetrahydrofuran; hexane / 0.08 h / -95 °C

2.1: 89 percent / trityl perchlorate / CH₂Cl₂ / 2 h / 20 - 25 °C

3.1: t-BuOK / tetrahydrofuran / 0.17 h / 20 - 25 °C

3.2: 81 percent / tetrahydrofuran / 0.5 h / 20 - 25 °C

With n-butyllithium; potassium tert-butylate; triphenylmethyl perchlorate; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1055/s-2002-28521

Reference yield:

2,2,2-tris(ethylsulfanyl)-1-(4-isobutylphenyl)ethanone (467225-66-7) → S-ethyl α-(4-isobutylphenyl)-α-(ethylsulfanyl)thiopropionate (467225-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 89 percent / trityl perchlorate / CH₂Cl₂ / 2 h / 20 - 25 °C

2.1: t-BuOK / tetrahydrofuran / 0.17 h / 20 - 25 °C

2.2: 81 percent / tetrahydrofuran / 0.5 h / 20 - 25 °C

With potassium tert-butylate; triphenylmethyl perchlorate; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-2002-28521

upstream raw materials:

dimethyl sulfate

S-ethyl bis(ethylsulfanyl)(4-isobutylphenyl)thioacetate

methyl 4-iso-butylbenzoate

2,2,2-tris(ethylsulfanyl)-1-(4-isobutylphenyl)ethanone

Downstream raw materials:

ibuprofen

S-ethyl α-(4-isobutylphenyl)thiopropionate