tetramethyl 2-(4-chlorobenzoyl)propane-1,1,3,3-tetracarboxylate

Base Information

• Chemical Name: tetramethyl 2-(4-chlorobenzoyl)propane-1,1,3,3-tetracarboxylate
• CAS No.: 1605320-57-7
• Molecular Formula: C₁₈H₁₉ClO₉
• Molecular Weight: 414.796
• Mol file: 1605320-57-7.mol

Synonyms:tetramethyl 2-(4-chlorobenzoyl)propane-1,1,3,3-tetracarboxylate

Chemical Property of tetramethyl 2-(4-chlorobenzoyl)propane-1,1,3,3-tetracarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tetramethyl 2-(4-chlorobenzoyl)propane-1,1,3,3-tetracarboxylate

There total 3 articles about tetramethyl 2-(4-chlorobenzoyl)propane-1,1,3,3-tetracarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

para-chloroacetophenone (99-91-2) + malonic acid dimethyl ester (108-59-8) → tetramethyl 2-(4-chlorobenzoyl)propane-1,1,3,3-tetracarboxylate (1605320-57-7)

Guidance literature:

With potassium iodide; potassium hydroxide; In methanol; at 20 ℃; for 3h; Electrochemical reaction; Green chemistry;

DOI:10.1039/c4cc01277a

Reference yield:

N-(2-(4-cholorophenyl)-2-oxoethyl)-4-methylbenzenesulfonamide (3932-22-7) + malonic acid dimethyl ester (108-59-8) → tetramethyl 2-(4-chlorobenzoyl)propane-1,1,3,3-tetracarboxylate (1605320-57-7)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 0.75h; Green chemistry;

DOI:10.1039/c9ob02451d

Reference yield:

N-(p-toluenesulfonyl)-2-(4-chlorophenyl)aziridine (97401-93-9) → tetramethyl 2-(4-chlorobenzoyl)propane-1,1,3,3-tetracarboxylate (1605320-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 0.75 h / 100 °C / Green chemistry

2: potassium tert-butylate / dimethyl sulfoxide / 0.75 h / 20 °C / Green chemistry

With potassium tert-butylate; dimethyl sulfoxide; In dimethyl sulfoxide;

DOI:10.1039/c9ob02451d

upstream raw materials:

para-chloroacetophenone

malonic acid dimethyl ester

N-(p-toluenesulfonyl)-2-(4-chlorophenyl)aziridine

N-(2-(4-cholorophenyl)-2-oxoethyl)-4-methylbenzenesulfonamide