4,4'-terephthaloyl bis(N-cyclohexyl-2-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepine-3-carboxamide)

Base Information

Chemical Name:4,4'-terephthaloyl bis(N-cyclohexyl-2-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepine-3-carboxamide)
CAS No.:1616367-17-9
Molecular Formula:C₅₂H₅₂N₆O₄
Molecular Weight:825.023
Hs Code.:

Synonyms:4,4'-terephthaloyl bis(N-cyclohexyl-2-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepine-3-carboxamide)

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Chemical Property of 4,4'-terephthaloyl bis(N-cyclohexyl-2-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepine-3-carboxamide)

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Technology Process of 4,4'-terephthaloyl bis(N-cyclohexyl-2-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepine-3-carboxamide)

There total 2 articles about 4,4'-terephthaloyl bis(N-cyclohexyl-2-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepine-3-carboxamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1631151-78-4
N¹,N⁴-bis((E)-1-cyclohexylaminocarbonyl-2-hydroxy-2-phenylethenyl)-N¹,N⁴-bis(2-nitrobenzyl)terephthalamide

: 1616367-17-9
4,4'-terephthaloyl bis(N-cyclohexyl-2-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepine-3-carboxamide)

Guidance literature:: With hydrogenchloride; tin(ll) chloride; In ethanol; for 0.75h; Reflux;
DOI:10.1039/c4ob00444b

Reference yield:

: 931-53-3
Cyclohexyl isocyanide

: 1074-12-0
phenylglyoxal hydrate

: 100-21-0
terephthalic acid

: 24835-08-3
2-nitrobenzylamine hydrochloride

: 1616367-17-9
4,4'-terephthaloyl bis(N-cyclohexyl-2-phenyl-4,5-dihydro-1H-benzo[e][1,4]diazepine-3-carboxamide)

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / 0.17 h

1.2: 0.25 h / 20 °C

1.3: 48 h / 20 °C

2.1: tin(ll) chloride; hydrogenchloride / ethanol / 0.75 h / Reflux

With hydrogenchloride; tin(ll) chloride; potassium hydroxide; In ethanol; 1.1: |Ugi Condensation / 1.2: |Ugi Condensation;
DOI:10.1039/c4ob00444b