2-NITROBENZYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 2-NITROBENZYLAMINE HYDROCHLORIDE
• CAS No.: 24835-08-3
• Molecular Formula: C7H8 N2 O2 . Cl H
• Molecular Weight: 188.614
• Hs Code.: 2921499090
• Mol file: 24835-08-3.mol

Synonyms:Benzenemethanamine,2-nitro-, monohydrochloride (9CI); Benzylamine, o-nitro-, hydrochloride (6CI);Benzylamine, o-nitro-, monohydrochloride (8CI); 2-Nitrobenzylaminehydrochloride

Chemical Property of 2-NITROBENZYLAMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.000853mmHg at 25°C
• Melting Point: 247oC (dec.)(lit.)
• Boiling Point: 300.2°C at 760 mmHg
• Flash Point: 135.4°C
• PSA: 71.84000
• LogP: 3.07900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2-Nitrophenyl)methanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Nitrobenzylamine hydrochloride may be used in chemical synthesis studies. Also reactant involved in synthesis of tetrahydroisoquinolines via Heck-aza-Michael reactions, aminomethylphenylamine scaffolds for factor Xa inhibition, squaryliamides for mannosyltransferase inhibition and fluorescent two-photon absorption benzothiadiazole dyes.

Technology Process of 2-NITROBENZYLAMINE HYDROCHLORIDE

There total 6 articles about 2-NITROBENZYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-(azidomethyl)-2-nitrobenzene (95668-86-3) → 2-nitrobenzylamine hydrochloride (24835-08-3)

Guidance literature:

1-(azidomethyl)-2-nitrobenzene; With triphenylphosphine; In tetrahydrofuran; water; for 6h; Inert atmosphere; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; for 3h; Reflux; Inert atmosphere;

DOI:10.1002/ejoc.201701329

Reference yield:

4-nitrobenzyl chloride (100-14-1) → 2-nitrobenzylamine hydrochloride (24835-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium azide; ammonium chloride / water / 48 h / 70 °C

2.1: triphenylphosphine / water; tetrahydrofuran / 6 h / Inert atmosphere; Reflux

2.2: 3 h / Reflux; Inert atmosphere

With sodium azide; ammonium chloride; triphenylphosphine; In tetrahydrofuran; water;

DOI:10.1002/ejoc.201701329

Reference yield:

2-nitrobenzyl chloride (612-23-7) → 2-nitrobenzylamine hydrochloride (24835-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium azide; ammonium chloride / water / 48 h / 70 °C

2.1: triphenylphosphine / water; tetrahydrofuran / 6 h / Inert atmosphere; Reflux

2.2: 3 h / Reflux; Inert atmosphere

With sodium azide; ammonium chloride; triphenylphosphine; In tetrahydrofuran; water;

DOI:10.1002/ejoc.201701329

upstream raw materials:

4,7-bis[4-(2-nitrobenzylamino)phenyl]-2,1,3-benzothiadiazole

4-nitrobenzyl chloride

4-nitrobenzyl chloride

2-nitrobenzyl chloride

Downstream raw materials:

2-(2-nitrobenzyl)isoindoline-1,3-dione

2-amino-1-benzylamine

N-(2-nitrobenzyl)urea

4,7-bis{4-[(N-(4-(2-nitrobenzylaminomethyl)phenyl)-N-phenyl)amino]phenyl}-2,1,3-benzothiadiazole

Refernces

• 1、 Ishi-I, Tsutomu,Nakamura, Nami,Mine, Tomonori,Imamura, Satoru,Shigeiwa, Motoyuki,Gorohmaru, Hideki,Maeda, Shuuichi. "Fluorescent two-photon absorption benzothiadiazole dyes having photoreleasing quenchers". scheme or table. p. 1042 - 1043. Retrieved 2010/06/17.