N-cyclopropyl-2-{4-[1-(4-ethoxy-phenyl)-piperidin-4-yl]-phenyl}-propionamide

Base Information

Chemical Name:N-cyclopropyl-2-{4-[1-(4-ethoxy-phenyl)-piperidin-4-yl]-phenyl}-propionamide
CAS No.:1441255-26-0
Molecular Formula:C₂₅H₃₂N₂O₂
Molecular Weight:392.541
Hs Code.:

Synonyms:N-cyclopropyl-2-{4-[1-(4-ethoxy-phenyl)-piperidin-4-yl]-phenyl}-propionamide

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Chemical Property of N-cyclopropyl-2-{4-[1-(4-ethoxy-phenyl)-piperidin-4-yl]-phenyl}-propionamide

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Technology Process of N-cyclopropyl-2-{4-[1-(4-ethoxy-phenyl)-piperidin-4-yl]-phenyl}-propionamide

There total 7 articles about N-cyclopropyl-2-{4-[1-(4-ethoxy-phenyl)-piperidin-4-yl]-phenyl}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1441257-58-4
2-{4-[1-(4-ethoxy-phenyl)-piperidin-4-yl]-phenyl}-propionic acid

: 765-30-0
Cyclopropylamine

: 1441255-26-0
N-cyclopropyl-2-{4-[1-(4-ethoxy-phenyl)-piperidin-4-yl]-phenyl}-propionamide

Guidance literature:: 2-{4-[1-(4-ethoxy-phenyl)-piperidin-4-yl]-phenyl}-propionic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

Cyclopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 1441257-42-6
2-(4-piperidin-4-yl-phenyl)-propionic acid methyl ester

: 1441255-26-0
N-cyclopropyl-2-{4-[1-(4-ethoxy-phenyl)-piperidin-4-yl]-phenyl}-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium pivalate; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 70 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 12 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium pivalate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; johnphos; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1441257-15-3
4-[4-(1-methoxycarbonyl-ethyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1441255-26-0
N-cyclopropyl-2-{4-[1-(4-ethoxy-phenyl)-piperidin-4-yl]-phenyl}-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; palladium on activated charcoal / methanol / 1 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 - 40 °C

3.1: sodium pivalate; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 70 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 12 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; hydrogen; sodium pivalate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; johnphos; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;