1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydropyridazine-3-carboxamide trifluoroacetate

Base Information

Chemical Name:1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydropyridazine-3-carboxamide trifluoroacetate
CAS No.:1234349-74-6
Molecular Formula:C₂HF₃O₂*C₂₁H₂₄N₆O₃
Molecular Weight:522.484
Hs Code.:

Synonyms:1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydropyridazine-3-carboxamide trifluoroacetate

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Chemical Property of 1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydropyridazine-3-carboxamide trifluoroacetate

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Technology Process of 1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydropyridazine-3-carboxamide trifluoroacetate

There total 10 articles about 1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydropyridazine-3-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60184-73-8
6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid amide

: 1092568-89-2
{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]phenyl}-methanol

: 76-05-1
trifluoroacetic acid

: 1234349-74-6
1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydropyridazine-3-carboxamide trifluoroacetate

Guidance literature:: 6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid amide; {3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]phenyl}-methanol; With di-tert-butyl-diazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 18h;

trifluoroacetic acid;

Reference yield:

: 1092566-65-8
methyl 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoate

: 1234349-74-6
1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydropyridazine-3-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen; water; acetic acid / Raney nickel / methanol / 18 h / 20 °C / 760.05 Torr

2: sodium methylate / methanol / 1.17 h / 60 °C

3: water; sulfuric acid / 4 h / Reflux

4: thionyl chloride / 6 h / 80 °C

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

6: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

7: di-tert-butyl-diazodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 18 h / 20 °C

With thionyl chloride; di-tert-butyl-diazodicarboxylate; di-isopropyl azodicarboxylate; sulfuric acid; water; hydrogen; sodium methylate; diisobutylaluminium hydride; acetic acid; triphenylphosphine; Raney nickel; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1877-72-1
3-Cyanobenzoic acid

: 1234349-74-6
1-{3-[5-(3-dimethylaminopropoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydropyridazine-3-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate; hydroxylamine hydrochloride / methanol / 15 h / 30 °C / Reflux

2: acetic acid / 14 h / 118 °C

3: sulfuric acid / 18 h / Reflux

4: hydrogen; water; acetic acid / Raney nickel / methanol / 18 h / 20 °C / 760.05 Torr

5: sodium methylate / methanol / 1.17 h / 60 °C

6: water; sulfuric acid / 4 h / Reflux

7: thionyl chloride / 6 h / 80 °C

8: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

9: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

10: di-tert-butyl-diazodicarboxylate / N,N-dimethyl-formamide; tetrahydrofuran / 18 h / 20 °C

With thionyl chloride; di-tert-butyl-diazodicarboxylate; di-isopropyl azodicarboxylate; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; sodium methylate; diisobutylaluminium hydride; potassium carbonate; acetic acid; triphenylphosphine; Raney nickel; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;