1-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-β-L-furanosyl)thymine

Base Information

Chemical Name:1-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-β-L-furanosyl)thymine
CAS No.:765311-86-2
Molecular Formula:C₁₉H₁₅FN₂O₅
Molecular Weight:370.337
Hs Code.:

Synonyms:1-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-β-L-furanosyl)thymine

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Chemical Property of 1-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-β-L-furanosyl)thymine

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Technology Process of 1-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-β-L-furanosyl)thymine

There total 6 articles about 1-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-β-L-furanosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.7%

: 765311-76-0
2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-5-O-benzoyl-1-O-acetyl-L-furanose

: 65-71-4,28806-14-6,691841-57-3
thymin

: 765311-86-2
1-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-β-L-furanosyl)thymine

: 1-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-α-L-furanosyl)thymine

Guidance literature:: thymin; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; at 50 - 60 ℃; for 2h;

2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-5-O-benzoyl-1-O-acetyl-L-furanose; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jo049597h

Reference yield:

: 765311-74-8
Benzoic acid (E)-(S)-2-ethynyl-3-fluoro-2-hydroxy-5-oxo-pent-3-enyl ester

: 765311-86-2
1-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-β-L-furanosyl)thymine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85.2 percent / pyridine / 3 h / 20 °C

2.1: N,O-bis(trimethylsiyl)acetamide / acetonitrile / 2 h / 50 - 60 °C

2.2: 54.7 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile;
DOI:10.1021/jo049597h

Reference yield:

: 765311-72-6
(2S,5R)-1-O-benzoyl-5,6-dihydroxy-3E-fluoro-2-hydroxy-2-ethynyl-3-hexene

: 765311-86-2
1-(5-O-benzoyl-2,3-dideoxy-2,3-didehydro-3-fluoro-4-ethynyl-β-L-furanosyl)thymine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91.1 percent / sodium periodate / ethanol; H₂O / 0.5 h / 20 °C

2.1: 85.2 percent / pyridine / 3 h / 20 °C

3.1: N,O-bis(trimethylsiyl)acetamide / acetonitrile / 2 h / 50 - 60 °C

3.2: 54.7 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C

With pyridine; sodium periodate; N,O-bis-(trimethylsilyl)-acetamide; In ethanol; water; acetonitrile;
DOI:10.1021/jo049597h