(3-methoxy-4-((8-(1-methyl-1H-pyrazol-4-yl) pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

Base Information

Chemical Name:(3-methoxy-4-((8-(1-methyl-1H-pyrazol-4-yl) pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone
CAS No.:1578243-87-4
Molecular Formula:C₂₃H₂₃N₇O₃
Molecular Weight:445.481
Hs Code.:

Synonyms:(3-methoxy-4-((8-(1-methyl-1H-pyrazol-4-yl) pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

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Chemical Property of (3-methoxy-4-((8-(1-methyl-1H-pyrazol-4-yl) pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

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Technology Process of (3-methoxy-4-((8-(1-methyl-1H-pyrazol-4-yl) pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

There total 8 articles about (3-methoxy-4-((8-(1-methyl-1H-pyrazol-4-yl) pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1400287-07-1
(4-amino-3-methoxyphenyl)(3-methoxyazetidin-1-yl)methanone

: 1578246-00-0
8-(1-methyl-1H-pyrazol-4-yl)-2-(methylsulfonyl)pyrido[3,4-d]pyrimidine

: 1578243-87-4
(3-methoxy-4-((8-(1-methyl-1H-pyrazol-4-yl) pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

Guidance literature:: With trifluoroacetic acid; In 2,2,2-trifluoroethanol; at 80 ℃; for 23h; Reflux;

Reference yield:

: 2486-69-3
3-methoxy-4-aminobenzoic acid

: 1578243-87-4
(3-methoxy-4-((8-(1-methyl-1H-pyrazol-4-yl) pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: HATU; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: trifluoroacetic acid / 2,2,2-trifluoroethanol / 23 h / 80 °C / Reflux

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; 2,2,2-trifluoroethanol;

Reference yield:

: 50593-92-5
5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid

: 1578243-87-4
(3-methoxy-4-((8-(1-methyl-1H-pyrazol-4-yl) pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)(3-methoxyazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / 24 h / Reflux

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; tetrahydrofuran / 18 h / 65 °C

3.1: ammonia / methanol / 18 h / 85 °C

3.2: 2 h / 90 °C

4.1: trichlorophosphate / 18 h / 70 °C

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; tetrahydrofuran / 18 h / 65 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C

7.1: trifluoroacetic acid / 2,2,2-trifluoroethanol / 23 h / 80 °C / Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; ammonia; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; 2,2,2-trifluoroethanol; water;