50593-92-5

Basic information

• Product Name: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid
• Synonyms: 5-BROMO-2-METHYLSULFANYL-PYRIMIDINE-4-CARBOXYLIC ACID;5-BROMO-2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLIC ACID;5-BROMO-2-(METHYLSULPHANYL)PYRIMIDINE-4-CARBOXYLIC ACID;5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLIC ACID;5-BROMO-2-(METHYLTHIO)PYRIMIDINE-4-CARB&;5-Bromo-2-(Methylsulfanyl)-4-P;5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid ,97%;5-Bromo-2-(methylsulfanyl)-4-pyrimidinecarboxylic acid ,97%
• CAS NO: 50593-92-5
• Molecular Formula: C₆H₅BrN₂O₂S
• Molecular Weight: 249.09
• Product Categories: Acids and Derivatives;Heterocycles;pharmacetical;Carboxylic Acids;Pyrazines, Pyrimidines & Pyridazines;Heterocycle intermediates;Carboxylic Acids;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Heterocycle-Pyrimidine series
• Mol File: 50593-92-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 158-162 °C (dec.)
• Boiling Point: 414.5 °C at 760 mmHg
• Flash Point: 204.5 °C
• Appearance: beige solid.
• Density: 1.91 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.31±0.10(Predicted)
• CAS DataBase Reference: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid(50593-92-5)
• EPA Substance Registry System: 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid(50593-92-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36/37-28
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 50593-92-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H5BrN2O2S/c1-12-6-8-2-3(7)4(9-6)5(10)11/h2H,1H3,(H,10,11)

Upstream product

• 488-11-9 mucobromic acid 
• 867-44-7 S-Methylisothiourea sulfate 
• 14527-26-5 2-methylisothiourea sulphate 
• 147895-43-0 S-methylisothiourea hemisulphate 
• 90994-06-2 (2E)-2,3-dibromo-4-oxobut-2-enoic acid 
• 4338-95-8 S-methylthiouronium iodide 
• 2986-19-8 carbamimidothioic acid methyl ester 

Downstream Products

• 100130-05-0 5-amino-2-methylsulfanylpyrimidine-4-carboxylic acid 
• 14001-67-3 5-bromo-2-methylthiopyrimidine 
• 30321-94-9 2-Methansulfonyl-5-brom-4-pyrimidincarbonsaeure 
• 110099-97-3 5-benzoyl-2-methylthiopyrimidine 
• 110100-05-5 5-benzoyl-2-methylsulphonylpyrimidine 
• 111253-05-5 5-(4-anisoyl)-2-methylthiopyrimidine 
• 111253-09-9 5-(4-anisoyl)-2-methylsulfonylpyrimidine 
• 111253-06-6 2-methylthio-5-(3-trifluoromethylbenzoyl)pyrimidine 
• 111253-10-2 2-methylsulfonyl-5-(3-trifluoromethylbenzoyl)pyrimidine 
• 1126-44-9 2-methylsulfanylpyrimidine-4-carboxylic acid 
• 50593-91-4 methyl 5-bromo-2-(methylsulfanyl)pyrimidine-4-carboxylate 
• 1578246-82-8 8-chloro-N-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methylpyrido[3,4-d]pyrimidin-2-amine 

Relevant articles and documents

PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

The purpose of the present invention is to provide a compound having an excellent CDK4/6 inhibiting activity. The present invention is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof.

IMIDAZOPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER

A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R3, R4, R6, and R7 are as defined herein.

7H-PYRIDO[3,4-D]PYRIMIDIN-8-ONES, THEIR MANUFACTURE AND USE AS PROTEIN KINASE INHIBITORS

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as we