ethyl 2-(benzyl(2-((4-cyanophenoxy)methyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-2-oxoacetate

Base Information

Chemical Name:ethyl 2-(benzyl(2-((4-cyanophenoxy)methyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-2-oxoacetate
CAS No.:1415680-06-6
Molecular Formula:C₂₇H₂₄N₂O₆
Molecular Weight:472.497
Hs Code.:

Synonyms:ethyl 2-(benzyl(2-((4-cyanophenoxy)methyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-2-oxoacetate

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Chemical Property of ethyl 2-(benzyl(2-((4-cyanophenoxy)methyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-2-oxoacetate

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Technology Process of ethyl 2-(benzyl(2-((4-cyanophenoxy)methyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-2-oxoacetate

There total 5 articles about ethyl 2-(benzyl(2-((4-cyanophenoxy)methyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1415680-04-4
4-((6-(benzylamino)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methoxy)benzonitrile

: 4755-77-5
Ethyl oxalyl chloride

: 1415680-06-6
ethyl 2-(benzyl(2-((4-cyanophenoxy)methyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-2-oxoacetate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2012.10.001

Reference yield:

: 1415680-02-2
C₁₆H₁₄N₂O₃

: 1415680-06-6
ethyl 2-(benzyl(2-((4-cyanophenoxy)methyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-2-oxoacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 12 h / 20 °C / Inert atmosphere; Molecular sieve

1.2: 1 h / Molecular sieve; Inert atmosphere

2.1: triethylamine / dichloromethane / 2 h / 20 °C

With triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2012.10.001

Reference yield:

: 3316-09-4
1,2-dihydroxy-4-nitrobenzene

: 1415680-06-6
ethyl 2-(benzyl(2-((4-cyanophenoxy)methyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-2-oxoacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 12 h / 80 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 48.5 h / 0 °C / Reflux

3.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 18751.9 Torr

4.1: methanol / 12 h / 20 °C / Inert atmosphere; Molecular sieve

4.2: 1 h / Molecular sieve; Inert atmosphere

5.1: triethylamine / dichloromethane / 2 h / 20 °C

With di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; 2.1: |Mitsunobu Displacement;
DOI:10.1016/j.ejmech.2012.10.001