2-chloro-4-(3-nitrophenoxy)-5-(pyridin-3-yl)-7-{[2(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:2-chloro-4-(3-nitrophenoxy)-5-(pyridin-3-yl)-7-{[2(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:1428775-84-1
Molecular Formula:C₂₃H₂₄ClN₅O₄Si
Molecular Weight:498.013
Hs Code.:

Synonyms:2-chloro-4-(3-nitrophenoxy)-5-(pyridin-3-yl)-7-{[2(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Property of 2-chloro-4-(3-nitrophenoxy)-5-(pyridin-3-yl)-7-{[2(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

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Technology Process of 2-chloro-4-(3-nitrophenoxy)-5-(pyridin-3-yl)-7-{[2(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

There total 5 articles about 2-chloro-4-(3-nitrophenoxy)-5-(pyridin-3-yl)-7-{[2(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1428775-83-0
2-chloro-5-iodo-4-(3-nitrophenoxy)-7-{[2(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

: 1692-25-7
3-pyridylboronic acid

: 1428775-84-1
2-chloro-4-(3-nitrophenoxy)-5-(pyridin-3-yl)-7-{[2(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; at 20 - 60 ℃; for 25h;

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 1428775-84-1
2-chloro-4-(3-nitrophenoxy)-5-(pyridin-3-yl)-7-{[2(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 6 h / 80 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

4.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 25 h / 20 - 60 °C

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; sodium carbonate; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1404364-72-2
2,4-dichloro-5-iodo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

: 1428775-84-1
2-chloro-4-(3-nitrophenoxy)-5-(pyridin-3-yl)-7-{[2(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 25 h / 20 - 60 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;