N-[(2Z)-3-butyl-5-oxido[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-[(2Z)-3-butyl-5-oxido[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide
CAS No.:1311318-91-8
Molecular Formula:C₂₁H₂₂F₃N₃O₄S
Molecular Weight:469.485
Hs Code.:

Synonyms:N-[(2Z)-3-butyl-5-oxido[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide

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Chemical Property of N-[(2Z)-3-butyl-5-oxido[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide

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Technology Process of N-[(2Z)-3-butyl-5-oxido[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide

There total 5 articles about N-[(2Z)-3-butyl-5-oxido[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1231955-18-2
N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide

: 1311318-91-8
N-[(2Z)-3-butyl-5-oxido[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1231955-35-3
N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-fluoro-5-(trifluoromethyl)benzamide

: 1311318-91-8
N-[(2Z)-3-butyl-5-oxido[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

1.2: 4 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 115029-23-7
2-fluoro-5-(trifluoromethyl)benzoic acid

: 1311318-91-8
N-[(2Z)-3-butyl-5-oxido[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; tetrahydrofuran / 12 h / 20 °C

2.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; tetra-(n-butyl)ammonium iodide; tetraethylammonium iodide / toluene / 12 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

3.2: 4 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C

With tetraethylammonium iodide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;