9-hydroxy-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one

Base Information

• Chemical Name: 9-hydroxy-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
• CAS No.: 869802-31-3
• Molecular Formula: C₁₇H₁₃N₃O₂S
• Molecular Weight: 323.375
• Mol file: 869802-31-3.mol

Synonyms:9-hydroxy-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one

Chemical Property of 9-hydroxy-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-hydroxy-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one

There total 3 articles about 9-hydroxy-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

9-(4'-methoxybenzyloxy)-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one (869802-30-2) → 9-hydroxy-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one (869802-31-3)

Guidance literature:

With trifluoroacetic acid; at 0 ℃; for 1.2h;

DOI:10.1021/jm0504407

Reference yield:

5-amino-4-(4'-methoxybenzyloxy)thieno[8,9-b]pyridine-6-carboxylic acid methyl ester (869802-28-8) → 9-hydroxy-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one (869802-31-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / 10 h / Heating

2: 39 percent / p-TsOH / toluene / 1 h / 160 °C / microwave irradiation

3: 100 percent / TFA / 1.2 h / 0 °C

With toluene-4-sulfonic acid; trifluoroacetic acid; In toluene;

DOI:10.1016/j.bmcl.2006.06.053

Reference yield:

4-(4'-methoxybenzyloxy)-5-(dimethylaminomethyleneamino)thieno[8,9-b]pyridine-6-carboxylic acid methyl ester → 9-hydroxy-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one (869802-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 39 percent / p-TsOH / toluene / 1 h / 160 °C / microwave irradiation

2: 100 percent / TFA / 1.2 h / 0 °C

With toluene-4-sulfonic acid; trifluoroacetic acid; In toluene;

DOI:10.1016/j.bmcl.2006.06.053

upstream raw materials:

9-(4'-methoxybenzyloxy)-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one

5-amino-4-(4'-methoxybenzyloxy)thieno[8,9-b]pyridine-6-carboxylic acid methyl ester

Downstream raw materials:

9-(trifluoromethanesulfonyl)-3-(4'-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one