(R)-methyl 2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetate

Base Information

Chemical Name:(R)-methyl 2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetate
CAS No.:1609646-58-3
Molecular Formula:C₁₅H₁₄N₂O₄S
Molecular Weight:318.353
Hs Code.:

Synonyms:(R)-methyl 2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetate

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Chemical Property of (R)-methyl 2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetate

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Technology Process of (R)-methyl 2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetate

There total 3 articles about (R)-methyl 2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 131490-25-0
1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxylic acid

: 19883-41-1,13226-98-7
D-phenylglycine methyl ester hydrochloride

: 1609646-58-3
(R)-methyl 2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 0 ℃; for 12.1667h;
DOI:10.1016/j.bmcl.2014.03.097

Reference yield:

: 1609646-56-1
C₆H₅BrNO₃⁽¹⁺⁾

: 1609646-58-3
(R)-methyl 2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: sodiumsulfide nonahydrate; sodium hydrogen sulfide / water / 24 h / 70 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12.17 h / 0 °C

With sodium hydrogen sulfide; sodiumsulfide nonahydrate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; water;
DOI:10.1016/j.bmcl.2014.03.097

Reference yield:

: 21190-87-4
6-bromo-pyridine-2-carboxylic acid

: 1609646-58-3
(R)-methyl 2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: dihydrogen peroxide / trifluoroacetic acid / 12 h / 80 °C

2: sodiumsulfide nonahydrate; sodium hydrogen sulfide / water / 24 h / 70 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12.17 h / 0 °C

With sodium hydrogen sulfide; sodiumsulfide nonahydrate; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; water; trifluoroacetic acid;
DOI:10.1016/j.bmcl.2014.03.097