(R)-2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetic acid

Base Information

Chemical Name:(R)-2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetic acid
CAS No.:1609646-55-0
Molecular Formula:C₁₄H₁₂N₂O₄S
Molecular Weight:304.326
Hs Code.:

Synonyms:(R)-2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetic acid

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Chemical Property of (R)-2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetic acid

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Technology Process of (R)-2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetic acid

There total 3 articles about (R)-2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1609646-58-3
(R)-methyl 2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetate

: 1609646-55-0
(R)-2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 0 ℃; for 1h;
DOI:10.1016/j.bmcl.2014.03.097

Reference yield:

: 1609646-56-1
C₆H₅BrNO₃⁽¹⁺⁾

: 1609646-55-0
(R)-2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodiumsulfide nonahydrate; sodium hydrogen sulfide / water / 24 h / 70 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12.17 h / 0 °C

3: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 1 h / 0 °C

With sodium hydrogen sulfide; sodiumsulfide nonahydrate; lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2014.03.097

Reference yield:

: 21190-87-4
6-bromo-pyridine-2-carboxylic acid

: 1609646-55-0
(R)-2-(1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamido)-2-phenylacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dihydrogen peroxide / trifluoroacetic acid / 12 h / 80 °C

2: sodiumsulfide nonahydrate; sodium hydrogen sulfide / water / 24 h / 70 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12.17 h / 0 °C

4: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 1 h / 0 °C

With sodium hydrogen sulfide; sodiumsulfide nonahydrate; lithium hydroxide monohydrate; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; trifluoroacetic acid;
DOI:10.1016/j.bmcl.2014.03.097