(R)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide

Base Information

Chemical Name:(R)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide
CAS No.:1448335-11-2
Molecular Formula:C₁₆H₁₄Cl₂N₂O₂
Molecular Weight:337.205
Hs Code.:

Synonyms:(R)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide

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Chemical Property of (R)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide

Chemical Property:

Purity/Quality:

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Technology Process of (R)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide

There total 6 articles about (R)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448336-33-1
2,3-dihydrofuro[2,3-b]pyridine-3-carboxylic acid

: 150517-76-3
2,4-dichloro-6-methylbenzylamine

: 1448335-11-2
(R)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide

: 1448335-12-3
(S)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

: 1448336-25-1
rac-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide

: 1448335-11-2
(R)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide

: 1448335-12-3
(S)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide

Guidance literature:: With ChiralPak IC; In ethanol; n-heptane; Resolution of racemate;

Reference yield:

: 193284-85-4
furo[2,3-b]pyridine-3-carboxylic acid methyl ester

: 1448335-11-2
(R)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide

: 1448335-12-3
(S)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid 2,4-dichloro-6-methyl-benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate; hydrogen; palladium hydroxide, 20 wt% on carbon / methanol / 20 h / Inert atmosphere

2: lithium hydroxide monohydrate; water / methanol; ethanol / 1 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane / 6 h / 20 °C

With lithium hydroxide monohydrate; palladium hydroxide, 20 wt% on carbon; water; hydrogen; sodium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane;