N-[2-(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzenesulfonylamino)ethyl]acetamide

Base Information

Chemical Name:N-[2-(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzenesulfonylamino)ethyl]acetamide
CAS No.:1444121-82-7
Molecular Formula:C₂₂H₃₁ClN₁₀O₄S
Molecular Weight:567.072
Hs Code.:

Synonyms:N-[2-(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzenesulfonylamino)ethyl]acetamide

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Chemical Property of N-[2-(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzenesulfonylamino)ethyl]acetamide

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Technology Process of N-[2-(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzenesulfonylamino)ethyl]acetamide

There total 4 articles about N-[2-(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzenesulfonylamino)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 775530-61-5
3,5-diamino-6-chloro-N-[(methylsulfanyl)methanimidoyl]pyrazine-2-carboxamide

: 1444124-22-4
C₁₆H₂₆N₄O₃S

: 1444121-82-7
N-[2-(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzenesulfonylamino)ethyl]acetamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 70 ℃;

Reference yield:

: 1458-01-1
3,5-diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester

: 1444121-82-7
N-[2-(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzenesulfonylamino)ethyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / methanol / 3 h / Reflux

2.1: trifluorormethanesulfonic acid / 1 h / Cooling with ice

2.2: 4 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran; tert-butyl methyl ether / 20 °C

4.1: triethylamine / N,N-dimethyl-formamide / 70 °C

With trifluorormethanesulfonic acid; water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; tert-butyl methyl ether; N,N-dimethyl-formamide;

Reference yield:

: 4878-36-8
3,5-diamino-6-chloro-pyrazine-2-carboxylic acid

: 1444121-82-7
N-[2-(4-{4-[N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)guanidino]piperidin-1-ylmethyl}benzenesulfonylamino)ethyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluorormethanesulfonic acid / 1 h / Cooling with ice

1.2: 4 h / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran; tert-butyl methyl ether / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 70 °C

With trifluorormethanesulfonic acid; water; triethylamine; sodium hydroxide; In tetrahydrofuran; tert-butyl methyl ether; N,N-dimethyl-formamide;