(3R,4S)-4-((R)-1-Hydroxy-but-3-ynyl)-3-methoxy-1-(4-methoxy-phenyl)-azetidin-2-one

Base Information

• Chemical Name: (3R,4S)-4-((R)-1-Hydroxy-but-3-ynyl)-3-methoxy-1-(4-methoxy-phenyl)-azetidin-2-one
• CAS No.: 444083-12-9
• Molecular Formula: C₁₅H₁₇NO₄
• Molecular Weight: 275.304
• Mol file: 444083-12-9.mol

Synonyms:(3R,4S)-4-((R)-1-Hydroxy-but-3-ynyl)-3-methoxy-1-(4-methoxy-phenyl)-azetidin-2-one

Chemical Property of (3R,4S)-4-((R)-1-Hydroxy-but-3-ynyl)-3-methoxy-1-(4-methoxy-phenyl)-azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4S)-4-((R)-1-Hydroxy-but-3-ynyl)-3-methoxy-1-(4-methoxy-phenyl)-azetidin-2-one

There total 2 articles about (3R,4S)-4-((R)-1-Hydroxy-but-3-ynyl)-3-methoxy-1-(4-methoxy-phenyl)-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

propargyl bromide (106-96-7) + 3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbaldehyde (180062-99-1) → (3R,4S)-4-((R)-1-Hydroxy-but-3-ynyl)-3-methoxy-1-(4-methoxy-phenyl)-azetidin-2-one (444083-12-9)

Guidance literature:

With ammonium chloride; zinc; In tetrahydrofuran; water; at 20 ℃; for 12h;

DOI:10.1002/ejoc.201000710

Reference yield:

propargyl bromide (106-96-7) + 3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbaldehyde (180062-99-1) → (3R,4S)-4-((R)-1-Hydroxy-buta-2,3-dienyl)-3-methoxy-1-(4-methoxy-phenyl)-azetidin-2-one + (3R,4S)-4-((R)-1-Hydroxy-but-3-ynyl)-3-methoxy-1-(4-methoxy-phenyl)-azetidin-2-one (444083-12-9)

Guidance literature:

With indium; ammonium chloride; In tetrahydrofuran; Further Variations:; Reagents; Product distribution;

DOI:10.1002/1521-3765(20020402)8:7<1719::AID-CHEM1719>3.0.CO;2-U

Reference yield: 100.0%

(3R,4S)-4-((R)-1-Hydroxy-but-3-ynyl)-3-methoxy-1-(4-methoxy-phenyl)-azetidin-2-one (444083-12-9) → C30H32N2O8 (1031797-13-3)

Guidance literature:

With copper diacetate; potassium carbonate; In acetonitrile; at 20 ℃; for 168h;

DOI:10.1002/ejoc.200701083

upstream raw materials:

propargyl bromide

3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbaldehyde

Downstream raw materials:

C₂₇H₃₂N₂O₈

C₃₀H₃₂N₂O₈

C₁₅H₁₆BrNO₄

C₁₅H₁₇NO₄