N-(9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene-4-yl-methyl)benzamide

Base Information

• Chemical Name: N-(9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene-4-yl-methyl)benzamide
• CAS No.: 81885-62-3
• Molecular Formula: C₂₁H₁₉NOS
• Molecular Weight: 333.454

Synonyms:N-(9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene-4-yl-methyl)benzamide

Chemical Property of N-(9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene-4-yl-methyl)benzamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene-4-yl-methyl)benzamide

There total 5 articles about N-(9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene-4-yl-methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-aminomethyl-9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene (88458-45-1) + benzoyl chloride (98-88-4) → N-(9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene-4-yl-methyl)benzamide (81885-62-3)

Guidance literature:

With sodium hydroxide; at 22 ℃; for 3h;

DOI:10.1002/jhet.5570210132

Reference yield:

9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophen-4-one (1622-55-5) → N-(9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene-4-yl-methyl)benzamide (81885-62-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / NaBH₄ / ethanol / 2 h / Heating

2: 83 percent / PBr₃ / diethyl ether

3: 70 percent / benzene / 12 h / Heating

4: LiAlH₄, AlCl₃ / diethyl ether / 1) reflux, 2 h; 2) room temp., 60 h

5: 90 percent / 10percent aq. NaOH / 3 h / 22 °C

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; aluminium trichloride; phosphorus tribromide; In diethyl ether; ethanol; benzene;

DOI:10.1002/jhet.5570210132

Reference yield:

4-cyano-9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene (81885-59-8) → N-(9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene-4-yl-methyl)benzamide (81885-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄, AlCl₃ / diethyl ether / 1) reflux, 2 h; 2) room temp., 60 h

2: 90 percent / 10percent aq. NaOH / 3 h / 22 °C

With sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether;

DOI:10.1002/jhet.5570210132

upstream raw materials:

4-aminomethyl-9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene

benzoyl chloride

9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophen-4-one

4-hydroxy-9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene

Downstream raw materials:

1,6,7,11b-tetrahydro-3-phenylbenzo<1,2>cyclohepta<3,4,5-hi>thieno<3,4-c>pyridine

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