(2R)-3-hydroxy-2-(2-hydroxythiobenzoylamino)-N-methoxy-N-methylpropionamide

Base Information

Chemical Name:(2R)-3-hydroxy-2-(2-hydroxythiobenzoylamino)-N-methoxy-N-methylpropionamide
CAS No.:338461-14-6
Molecular Formula:C₁₂H₁₆N₂O₄S
Molecular Weight:284.336
Hs Code.:

Synonyms:(2R)-3-hydroxy-2-(2-hydroxythiobenzoylamino)-N-methoxy-N-methylpropionamide

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Chemical Property of (2R)-3-hydroxy-2-(2-hydroxythiobenzoylamino)-N-methoxy-N-methylpropionamide

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Technology Process of (2R)-3-hydroxy-2-(2-hydroxythiobenzoylamino)-N-methoxy-N-methylpropionamide

There total 4 articles about (2R)-3-hydroxy-2-(2-hydroxythiobenzoylamino)-N-methoxy-N-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 338461-19-1
(2R)-3-hydroxy-2-(2-hydroxybenzoylamino)-N-methoxy-N-methylpropionamide

: 338461-14-6
(2R)-3-hydroxy-2-(2-hydroxythiobenzoylamino)-N-methoxy-N-methylpropionamide

Guidance literature:: (2R)-3-hydroxy-2-(2-hydroxybenzoylamino)-N-methoxy-N-methylpropionamide; With Burgess Reagent; In tetrahydrofuran; Heating;

With hydrogen sulfide; triethylamine; In methanol; at 20 ℃; for 120h;
DOI:10.1016/S0040-4020(01)00012-6

Reference yield:

: 21615-34-9
2-Methoxybenzoyl chloride

: 338461-14-6
(2R)-3-hydroxy-2-(2-hydroxythiobenzoylamino)-N-methoxy-N-methylpropionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / Et₃N; DMAP / 20 °C / pH 13

2.1: 100 percent / TFA / CH₂Cl₂ / 3.5 h / 20 °C

3.1: 81 percent / BCl₃ / CH₂Cl₂; hexane / 20 °C

4.1: Burgess reagent / tetrahydrofuran / Heating

4.2: 85 percent / Et₃N; H₂S / methanol / 120 h / 20 °C

With dmap; Burgess Reagent; boron trichloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0040-4020(01)00012-6

Reference yield:

: 338461-18-0
(2R)-3-hydroxy-N-methoxy-2-(2-methoxybenzoylamino)-N-methylpropionamide

: 338461-14-6
(2R)-3-hydroxy-2-(2-hydroxythiobenzoylamino)-N-methoxy-N-methylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / BCl₃ / CH₂Cl₂; hexane / 20 °C

2.1: Burgess reagent / tetrahydrofuran / Heating

2.2: 85 percent / Et₃N; H₂S / methanol / 120 h / 20 °C

With Burgess Reagent; boron trichloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0040-4020(01)00012-6