5,5'-(isoquinoline-5,8-diylbis(ethyne-2,1-diyl))-bis(3-tert-butyl-2-hydroxybenzaldehyde)

Base Information

Chemical Name:5,5'-(isoquinoline-5,8-diylbis(ethyne-2,1-diyl))-bis(3-tert-butyl-2-hydroxybenzaldehyde)
CAS No.:1353436-09-5
Molecular Formula:C₃₅H₃₁NO₄
Molecular Weight:529.635
Hs Code.:

Synonyms:5,5'-(isoquinoline-5,8-diylbis(ethyne-2,1-diyl))-bis(3-tert-butyl-2-hydroxybenzaldehyde)

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Chemical Property of 5,5'-(isoquinoline-5,8-diylbis(ethyne-2,1-diyl))-bis(3-tert-butyl-2-hydroxybenzaldehyde)

Chemical Property:

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Technology Process of 5,5'-(isoquinoline-5,8-diylbis(ethyne-2,1-diyl))-bis(3-tert-butyl-2-hydroxybenzaldehyde)

There total 5 articles about 5,5'-(isoquinoline-5,8-diylbis(ethyne-2,1-diyl))-bis(3-tert-butyl-2-hydroxybenzaldehyde) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 913558-64-2
5,8-bis(ethynyl)isoquinoline

: 83816-59-5
3-tert-butyl-2-hydroxy-5-iodobenzaldehyde

: 1353436-09-5
5,5'-(isoquinoline-5,8-diylbis(ethyne-2,1-diyl))-bis(3-tert-butyl-2-hydroxybenzaldehyde)

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; at 45 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.polymer.2011.11.017

Reference yield:

: 88-18-6
2-tert-Butylphenol

: 1353436-09-5
5,5'-(isoquinoline-5,8-diylbis(ethyne-2,1-diyl))-bis(3-tert-butyl-2-hydroxybenzaldehyde)

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; magnesium chloride / tetrahydrofuran

2: iodine; sodium hydrogencarbonate / tetrahydrofuran; water / 12 h / Reflux

3: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 4 h / 45 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; sodium hydrogencarbonate; triethylamine; magnesium chloride; In tetrahydrofuran; water; 3: Sonogashira coupling;
DOI:10.1016/j.polymer.2011.11.017

Reference yield:

: 24623-65-2
3-tert-butyl-2-hydroxybenzaldehyde

: 1353436-09-5
5,5'-(isoquinoline-5,8-diylbis(ethyne-2,1-diyl))-bis(3-tert-butyl-2-hydroxybenzaldehyde)

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; sodium hydrogencarbonate / tetrahydrofuran; water / 12 h / Reflux

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 4 h / 45 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; water; 2: Sonogashira coupling;
DOI:10.1016/j.polymer.2011.11.017