2-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methylpropanenitrile
CAS No.:1415999-86-8
Molecular Formula:C₂₇H₂₁N₅O₂
Molecular Weight:447.496
Hs Code.:

Synonyms:2-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methylpropanenitrile

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Technology Process of 2-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methylpropanenitrile

There total 10 articles about 2-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.2%

: 1416000-76-4
2-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methyl propanenitrile

: 163105-89-3,600726-67-8
2-methoxy-pyridine-5-boronic acid

: 1415999-86-8
2-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; for 12h; Inert atmosphere; Reflux;

Reference yield: 76.2%

: 6-methoxy-3-pyridine boric acid

: 1416000-76-4
2-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methyl propanenitrile

: 1415999-86-8
2-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methylpropanenitrile

Guidance literature:

Reference yield:

: 1416000-72-0
2-(4-((6-chloro-3-(hydroxymethyl)-1,5-naphthyridin-4-yl)amino) phenyl)-2-methylpropionitrile

: 1415999-86-8
2-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane

2: acetic anhydride / N,N-dimethyl acetamide

With acetic anhydride; In dichloromethane; N,N-dimethyl acetamide;