2-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methyl propanenitrile

Base Information

• Chemical Name: 2-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methyl propanenitrile
• CAS No.: 1416000-76-4
• Molecular Formula: C₂₁H₁₅ClN₄O
• Molecular Weight: 374.829

Synonyms:2-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methyl propanenitrile

Chemical Property of 2-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methyl propanenitrile

Chemical Property:

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Technology Process of 2-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methyl propanenitrile

There total 9 articles about 2-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methyl propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(4-((6-chloro-3-formyl-1,5-naphthyridin-4-yl)amino)phenyl)-2-methylpropionitrile (1416000-74-2) → 2-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methyl propanenitrile (1416000-76-4)

Guidance literature:

With acetic anhydride; In N,N-dimethyl acetamide;

Reference yield: 79.0%

2-(4-((6-chloro-3-formyl-1,5-naphthyridin-4-yl)amino)phenyl)-2-methylpropionitrile (1416000-74-2) + acetic anhydride (108-24-7) → 2-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methyl propanenitrile (1416000-76-4)

Guidance literature:

In N,N-dimethyl acetamide; at 160 ℃; for 1h; Microwave irradiation;

Reference yield: 29.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 2-(4-((6-chloro-3-formyl-1,5-naphthyridin-4-yl)amino)phenyl)-2-methylpropionitrile (1416000-74-2) → 2-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methyl propanenitrile (1416000-76-4)

Guidance literature:

With potassium carbonate; In tert-butyl alcohol;

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

2-(4-((6-chloro-3-formyl-1,5-naphthyridin-4-yl)amino)phenyl)-2-methylpropionitrile

2-(4-((6-chloro-3-(hydroxymethyl)-1,5-naphthyridin-4-yl)amino) phenyl)-2-methylpropionitrile

4,6-dichloro-(1,5)-naphthyridine-3-carboxylic acid ethyl ester

Downstream raw materials:

2-(4-(2-(2-methoxypyrimidin-5-yl)-9-oxopyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methylpropanenitrile

2-(4-(2-(6-methoxypyridin-3-yl)-9-oxopyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methylpropanenitrile

2-(4-(2-(6-aminopyridin-3-yl)-9-oxopyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methylpropanenitrile

2-methyl-2-(4-(9-oxo-2-(quinolin-3-yl)pyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl) propanenitrile

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