1-{(2R,4S,5R)-4-Isothiocyanato-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-{(2R,4S,5R)-4-Isothiocyanato-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione
• CAS No.: 210903-71-2
• Molecular Formula: C₃₀H₂₈N₄O₃S
• Molecular Weight: 524.643

Synonyms:1-{(2R,4S,5R)-4-Isothiocyanato-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property of 1-{(2R,4S,5R)-4-Isothiocyanato-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property:

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Technology Process of 1-{(2R,4S,5R)-4-Isothiocyanato-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

There total 4 articles about 1-{(2R,4S,5R)-4-Isothiocyanato-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trityl chloride (76-83-5) → 1-{(2R,4S,5R)-4-Isothiocyanato-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (210903-71-2)

Guidance literature:

Multi-step reaction with 3 steps

2: H₂

3: Ambient temperature

With hydrogen;

DOI:10.1021/ja980629q

Reference yield:

1-((2R,4S,5R)-5-Aminomethyl-4-azido-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (143529-00-4) → 1-{(2R,4S,5R)-4-Isothiocyanato-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (210903-71-2)

Guidance literature:

Multi-step reaction with 3 steps

2: H₂

3: Ambient temperature

With hydrogen;

DOI:10.1021/ja980629q

Reference yield:

1-{(2R,4S,5R)-4-Azido-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione → 1-{(2R,4S,5R)-4-Isothiocyanato-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (210903-71-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂

2: Ambient temperature

With hydrogen;

DOI:10.1021/ja980629q

upstream raw materials:

pyridine-2-thione

trityl chloride

1-((2R,4S,5R)-5-Aminomethyl-4-azido-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Downstream raw materials:

1-[(2R,3S,5R)-2-Aminomethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-3-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-thiourea

C₃₂H₄₃N₁₁O₁₀S₂

C₅₁H₅₇N₁₁O₁₀S₂

C₄₃H₅₇N₁₅O₁₃S₃

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