1-[(2R,3S,5R)-2-Aminomethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-3-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-thiourea

Base Information

• Chemical Name: 1-[(2R,3S,5R)-2-Aminomethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-3-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-thiourea
• CAS No.: 210903-75-6
• Molecular Formula: C₂₁H₂₉N₇O₇S
• Molecular Weight: 523.57

Synonyms:1-[(2R,3S,5R)-2-Aminomethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-3-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-thiourea

Chemical Property of 1-[(2R,3S,5R)-2-Aminomethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-3-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-thiourea

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Technology Process of 1-[(2R,3S,5R)-2-Aminomethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-3-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-thiourea

There total 6 articles about 1-[(2R,3S,5R)-2-Aminomethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-3-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-3-{(2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[(trityl-amino)-methyl]-tetrahydro-furan-3-yl}-thiourea → 1-[(2R,3S,5R)-2-Aminomethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-3-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-thiourea (210903-75-6)

Guidance literature:

With acetic acid;

DOI:10.1021/ja980629q

Reference yield:

5'-amino-5'-deoxythymidine (25152-20-9) → 1-[(2R,3S,5R)-2-Aminomethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-3-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-thiourea (210903-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Ambient temperature

2: AcOH

With pyridine; acetic acid;

DOI:10.1021/ja980629q

Reference yield:

1-((2R,4S,5R)-5-Aminomethyl-4-azido-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (143529-00-4) → 1-[(2R,3S,5R)-2-Aminomethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-3-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-thiourea (210903-75-6)

Guidance literature:

Multi-step reaction with 5 steps

2: H₂

3: Ambient temperature

4: pyridine / Ambient temperature

5: AcOH

With pyridine; hydrogen; acetic acid;

DOI:10.1021/ja980629q

upstream raw materials:

5'-amino-5'-deoxythymidine

1-((2R,4S,5R)-5-Aminomethyl-4-azido-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

1-{(2R,4S,5R)-4-Isothiocyanato-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Downstream raw materials:

C₃₂H₄₃N₁₁O₁₀S₂

C₄₃H₅₇N₁₅O₁₃S₃

C₅₁H₅₇N₁₁O₁₀S₂

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