3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoic acid

Base Information

• Chemical Name: 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoic acid
• CAS No.: 1351945-21-5
• Molecular Formula: C₂₆H₂₀F₃N₃O₄
• Molecular Weight: 495.458

Synonyms:3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoic acid

Chemical Property of 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoic acid

There total 8 articles about 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

ethyl 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoate (1351945-47-5) → 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoic acid (1351945-21-5)

Guidance literature:

ethyl 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoate; With potassium hydroxide; In water; at 50 ℃; for 1h;

With acetic acid;

DOI:10.1021/ml200252b

Reference yield:

2-(trifluoromethyl)biphenyl-4-amine → 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoic acid (1351945-21-5)

Guidance literature:

Multi-step reaction with 6 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 17 h / 60 °C

2: bis(tri-t-butylphosphine)palladium⁽⁰⁾; cesium fluoride / 1,4-dioxane / 21.5 h / 20 - 80 °C / Inert atmosphere

3: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 4.5 h / 20 - 60 °C

4: 1,8-diazabicyclo[5.4.0] undec-7-ene; diethoxyphosphoryl-acetic acid ethyl ester; lithium chloride / acetonitrile / 1 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / ethanol / 8 h / Inert atmosphere

6: potassium hydroxide / water / 1 h / 50 °C

With sodium periodate; osmium(VIII) oxide; diethoxyphosphoryl-acetic acid ethyl ester; bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; 1,8-diazabicyclo[5.4.0] undec-7-ene; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; cesium fluoride; lithium chloride; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ml200252b

Reference yield:

(E)-ethyl 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)acrylate (1351945-46-4) → 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoic acid (1351945-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 8 h / Inert atmosphere

2: potassium hydroxide / water / 1 h / 50 °C

With palladium 10% on activated carbon; hydrogen; potassium hydroxide; In ethanol; water;

DOI:10.1021/ml200252b

upstream raw materials:

(E)-ethyl 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)acrylate

ethyl 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoate

7-bromo-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

7-bromo-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1351945-21-5 3-(1-methyl-4-oxo-3-(2-(trifluoromethyl)biphenyl-4-ylcarbamoyl)-1,4-dihydro-1,6-naphthyridin-7-yl)propanoic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send