7-bromo-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Base Information

Chemical Name:7-bromo-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide
CAS No.:1351945-32-8
Molecular Formula:C₂₄H₁₆BrF₃N₂O₂
Molecular Weight:501.302
Hs Code.:

Synonyms:7-bromo-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

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Chemical Property of 7-bromo-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

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Technology Process of 7-bromo-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

There total 4 articles about 7-bromo-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2-(trifluoromethyl)biphenyl-4-amine

: 1255785-59-1
7-bromo-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 1351945-32-8
7-bromo-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 17h;
DOI:10.1021/ml200252b

Reference yield:

: ethyl 7-bromo-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

: 1351945-32-8
7-bromo-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / methanol / 1 h / 60 °C

1.2: pH 6 / aq. phosphate buffer

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 17 h / 60 °C

With lithium hydroxide monohydrate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ml200252b

Reference yield:

: 591-19-5
m-Bromoaniline

: 1351945-32-8
7-bromo-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 17 h / 20 °C

1.2: 4 h / 220 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

3.1: lithium hydroxide monohydrate / methanol / 1 h / 60 °C

3.2: pH 6 / aq. phosphate buffer

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 17 h / 60 °C

With lithium hydroxide monohydrate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ml200252b