Chemical Property of Diffractaic acid
Chemical Property:
- Vapor Pressure:1.74E-15mmHg at 25°C
- Melting Point:189～190℃
- Boiling Point:604.9°Cat760mmHg
- PKA:2.66±0.25(Predicted)
- Flash Point:214.2°C
- PSA：102.29000
- Density:1.26g/cm3
- LogP:3.56040
- XLogP3:4.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:6
- Exact Mass:374.13655304
- Heavy Atom Count:27
- Complexity:536
- Purity/Quality:
-
≥98% *data from raw suppliers
Diffractaic Acid ≥95% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC(=C(C(=C1C(=O)O)O)C)OC(=O)C2=C(C(=C(C=C2C)OC)C)OC
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Description
Diffractaic acid is a lichen metabolite that has been found in P. magellanica and has diverse biological activities. It is cytotoxic to HCT116, HeLa, and MCF-7 cancer cells (IC50s = 42.2, 64.6, and 93.4 μM, respectively). Diffractaic acid inhibits growth of M. tuberculosis (MIC = 41.7 μM). In vivo, diffractaic acid (25-200 mg/kg) reduces neutrophil infiltration, lipid peroxidation, myeloperoxidase (MPx) activity, and the number of gastric lesions as well as reverses decreases in superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities induced by indomethacin in rat gastric mucosa. Diffractaic acid also has analgesic activity, reducing acetic acid-induced writhing and increasing the pressure pain threshold in mice.
