1-ethyl-6-(2-fluorophenyl)-8-iodo-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Base Information

Chemical Name:1-ethyl-6-(2-fluorophenyl)-8-iodo-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS No.:125030-12-8
Molecular Formula:C₁₈H₁₄FIN₄
Molecular Weight:432.239
Hs Code.:

Synonyms:1-ethyl-6-(2-fluorophenyl)-8-iodo-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

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Chemical Property of 1-ethyl-6-(2-fluorophenyl)-8-iodo-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

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Technology Process of 1-ethyl-6-(2-fluorophenyl)-8-iodo-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

There total 5 articles about 1-ethyl-6-(2-fluorophenyl)-8-iodo-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 125030-07-1
5-(2-fluorophenyl)-2-hydrazino-7-iodo-3H-1,4-benzodiazepine

: 115-80-0
Triethyl orthopropionate

: 125030-12-8
1-ethyl-6-(2-fluorophenyl)-8-iodo-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Guidance literature:: With silica gel; In toluene; for 3h; Heating;
DOI:10.1021/jm00107a048

Reference yield:

: 5-(2-fluorophenyl)-7-iodo-2-hydrazino-7-iodo-3H-1,4-benzodiazepine

: 115-80-0
Triethyl orthopropionate

: 125030-12-8
1-ethyl-6-(2-fluorophenyl)-8-iodo-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Guidance literature:: In 5,5-dimethyl-1,3-cyclohexadiene;

Reference yield:

: 1581-13-1
2-amino-2'-fluorobenzophenone

: 125030-12-8
1-ethyl-6-(2-fluorophenyl)-8-iodo-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Guidance literature:: Multi-step reaction with 7 steps

1: iodine monochloride / CH₂Cl₂ / 5 h / -60 °C

2: 10percent aq. Na₂CO₃ / CH₂Cl₂ / 0.5 h / 0 °C

3: liquid ammonia / CH₂Cl₂ / 16 h / Heating

4: HOAc / ethanol / 0.5 h / Heating

5: 80 percent / P₂S₅, NaHCO₃ / bis-(2-methoxy-ethyl) ether / 3 h / 80 - 85 °C

6: 83 percent / hydrazine / propan-2-ol; tetrahydrofuran / 0.25 h / Ambient temperature

7: 97 percent / silica gel / toluene / 3 h / Heating

With tetraphosphorus decasulfide; ammonia; silica gel; Iodine monochloride; sodium hydrogencarbonate; sodium carbonate; acetic acid; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; diethylene glycol dimethyl ether; isopropyl alcohol; toluene;
DOI:10.1021/jm00107a048