N-Boc-N-nosyl-2-(4-(2-(2-aminoethyl)-4-methoxyphenyl)-1-methoxycyclohex-3-enyl)ethanol

Base Information

Chemical Name:N-Boc-N-nosyl-2-(4-(2-(2-aminoethyl)-4-methoxyphenyl)-1-methoxycyclohex-3-enyl)ethanol
CAS No.:888030-01-1
Molecular Formula:C₂₉H₃₈N₂O₉S
Molecular Weight:590.695
Hs Code.:

Synonyms:N-Boc-N-nosyl-2-(4-(2-(2-aminoethyl)-4-methoxyphenyl)-1-methoxycyclohex-3-enyl)ethanol

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Chemical Property of N-Boc-N-nosyl-2-(4-(2-(2-aminoethyl)-4-methoxyphenyl)-1-methoxycyclohex-3-enyl)ethanol

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Technology Process of N-Boc-N-nosyl-2-(4-(2-(2-aminoethyl)-4-methoxyphenyl)-1-methoxycyclohex-3-enyl)ethanol

There total 11 articles about N-Boc-N-nosyl-2-(4-(2-(2-aminoethyl)-4-methoxyphenyl)-1-methoxycyclohex-3-enyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 888030-00-0
4-(2-(tert-butyldimethylsilyloxy)ethyl)-4-methoxycyclohex-1-enyl trifluoromethanesulfonate

: 888029-96-7
N-Boc-N-nosyl-2-(2-iodo-5-methoxyphenyl)ethanamine

: 888030-01-1
N-Boc-N-nosyl-2-(4-(2-(2-aminoethyl)-4-methoxyphenyl)-1-methoxycyclohex-3-enyl)ethanol

Guidance literature:: N-Boc-N-nosyl-2-(2-iodo-5-methoxyphenyl)ethanamine; With Pinacolborane; triethylamine; bis[2-(diphenylphosphino)phenyl] ether; palladium diacetate; In dichloromethane; at 85 ℃; for 1h;

4-(2-(tert-butyldimethylsilyloxy)ethyl)-4-methoxycyclohex-1-enyl trifluoromethanesulfonate; With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; at 81 ℃; for 2h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/ol060455e

Reference yield:

: 4-(2-hydroxy-ethyl)-4-methoxy-cyclohexanone

: 888030-01-1
N-Boc-N-nosyl-2-(4-(2-(2-aminoethyl)-4-methoxyphenyl)-1-methoxycyclohex-3-enyl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3.12 g / imidazole / dimethylformamide / 15 h / 20 °C

2.1: 98 percent / KHMDS / tetrahydrofuran / 4 h / -78 - 20 °C

3.1: DPEphos; triethylamine; pinacolborane / Pd(OAc)2 / CH₂Cl₂ / 1 h / 85 °C

3.2: Cs₂CO₃ / Pd(PPh₃)4 / dimethylsulfoxide / 2 h / 81 °C

3.3: 946 mg / TBAF / tetrahydrofuran / 3 h / 20 °C

With 1H-imidazole; pinacol borane; potassium hexamethylsilazane; triethylamine; bis[2-(diphenylphosphino)phenyl] ether; palladium diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3.2: Suzuki-Miyaura reaction;
DOI:10.1021/ol060455e

Reference yield:

: 888030-06-6
2-(2-iodo-5-methoxyphenyl)acetamide

: 888030-01-1
N-Boc-N-nosyl-2-(4-(2-(2-aminoethyl)-4-methoxyphenyl)-1-methoxycyclohex-3-enyl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: BH₃*THF / tetrahydrofuran / 3 h / Heating

1.2: 5.93 g / triethylamine / CH₂Cl₂ / 19 h / 20 °C

2.1: 98 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 20 °C

3.1: DPEphos; triethylamine; pinacolborane / Pd(OAc)2 / CH₂Cl₂ / 1 h / 85 °C

3.2: Cs₂CO₃ / Pd(PPh₃)4 / dimethylsulfoxide / 2 h / 81 °C

3.3: 946 mg / TBAF / tetrahydrofuran / 3 h / 20 °C

With dmap; borane-THF; Pinacolborane; triethylamine; bis[2-(diphenylphosphino)phenyl] ether; palladium diacetate; In tetrahydrofuran; dichloromethane; 3.2: Suzuki-Miyaura reaction;
DOI:10.1021/ol060455e