4-(2-(tert-butyldimethylsilyloxy)ethyl)-4-methoxycyclohex-1-enyl trifluoromethanesulfonate

Base Information

Chemical Name:4-(2-(tert-butyldimethylsilyloxy)ethyl)-4-methoxycyclohex-1-enyl trifluoromethanesulfonate
CAS No.:888030-00-0
Molecular Formula:C₁₆H₂₉F₃O₅SSi
Molecular Weight:418.55
Hs Code.:

Synonyms:4-(2-(tert-butyldimethylsilyloxy)ethyl)-4-methoxycyclohex-1-enyl trifluoromethanesulfonate

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Chemical Property of 4-(2-(tert-butyldimethylsilyloxy)ethyl)-4-methoxycyclohex-1-enyl trifluoromethanesulfonate

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Technology Process of 4-(2-(tert-butyldimethylsilyloxy)ethyl)-4-methoxycyclohex-1-enyl trifluoromethanesulfonate

There total 6 articles about 4-(2-(tert-butyldimethylsilyloxy)ethyl)-4-methoxycyclohex-1-enyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 888029-99-0
4-(2-(tert-butyldimethylsilyloxy)ethyl)-4-methoxycyclohexanone

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 888030-00-0
4-(2-(tert-butyldimethylsilyloxy)ethyl)-4-methoxycyclohex-1-enyl trifluoromethanesulfonate

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at -78 - 20 ℃; for 4h;
DOI:10.1021/ol060455e

Reference yield:

: 888029-98-9
8-allyl-8-methoxy-1,4-dioxaspiro[4.5]decane

: 888030-00-0
4-(2-(tert-butyldimethylsilyloxy)ethyl)-4-methoxycyclohex-1-enyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ozone / CH₂Cl₂; methanol / -78 °C

1.2: 96 percent / NaBH₄ / CH₂Cl₂; methanol / 4 h / 20 °C

2.1: 68 percent / PPTS / acetone; H₂O / 12 h / Heating

3.1: 3.12 g / imidazole / dimethylformamide / 15 h / 20 °C

4.1: 98 percent / KHMDS / tetrahydrofuran / 4 h / -78 - 20 °C

With 1H-imidazole; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; ozone; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol060455e

Reference yield:

: 429691-42-9
8-allyl-1,4-dioxaspiro[4.5]decan-8-ol

: 888030-00-0
4-(2-(tert-butyldimethylsilyloxy)ethyl)-4-methoxycyclohex-1-enyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / NaH / tetrahydrofuran; various solvent(s) / 3 h / 20 °C

2.1: ozone / CH₂Cl₂; methanol / -78 °C

2.2: 96 percent / NaBH₄ / CH₂Cl₂; methanol / 4 h / 20 °C

3.1: 68 percent / PPTS / acetone; H₂O / 12 h / Heating

4.1: 3.12 g / imidazole / dimethylformamide / 15 h / 20 °C

5.1: 98 percent / KHMDS / tetrahydrofuran / 4 h / -78 - 20 °C

With 1H-imidazole; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; sodium hydride; ozone; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol060455e