1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide

Base Information

Chemical Name:1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide
CAS No.:1620494-31-6
Molecular Formula:C₃₁H₂₉N₅O₄
Molecular Weight:535.602
Hs Code.:

Synonyms:1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide

Suppliers and Price of 1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Useful:

Uses Desmethyl-O-Benzyl Apixaban is a useful intermediate in the preparation of Apixaban (A726700). Apixaben is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation. Apixaban Impurity.

Technology Process of 1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide

There total 7 articles about 1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620494-29-2
1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

: 1620494-31-6
1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide

Guidance literature:: With sodium methylate; formamide; In N,N-dimethyl-formamide; at 0 - 5 ℃; Solvent;

Reference yield:

: C₃₆H₃₆N₄O₇

: 1620494-31-6
1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide

Guidance literature:: With ammonium hydroxide; In water; ethyl acetate;

Reference yield:

: 100-39-0
benzyl bromide

: 1620494-31-6
1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 25 - 60 °C

2.1: sodium sulfide / ethanol / 25 - 80 °C

3.1: sodium nitrite; hydrogenchloride / ethanol; water / 1 h / -5 °C

3.2: 1 h / 0 - 5 °C

4.1: triethylamine; potassium iodide / ethyl acetate / 25 - 80 °C

5.1: formamide; sodium methylate / N,N-dimethyl-formamide / 0 - 5 °C

With hydrogenchloride; sodium sulfide; sodium methylate; potassium carbonate; formamide; triethylamine; potassium iodide; sodium nitrite; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetone;