1-{4-[2-(4-chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyryl}-pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:1-{4-[2-(4-chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyryl}-pyrrolidine-2-carboxylic acid
CAS No.:898552-53-9
Molecular Formula:C₂₅H₂₄ClN₃O₅S
Molecular Weight:514.002
Hs Code.:

Synonyms:1-{4-[2-(4-chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyryl}-pyrrolidine-2-carboxylic acid

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Chemical Property of 1-{4-[2-(4-chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyryl}-pyrrolidine-2-carboxylic acid

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Technology Process of 1-{4-[2-(4-chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyryl}-pyrrolidine-2-carboxylic acid

There total 10 articles about 1-{4-[2-(4-chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyryl}-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 898552-43-7
4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyric acid 4-oxo-4H-benzo[d][1,2,3]triazin-3-yl ester

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 898552-53-9
1-{4-[2-(4-chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyryl}-pyrrolidine-2-carboxylic acid

Guidance literature:: With triethylamine; In chloroform; acetonitrile; for 16h;

Reference yield:

: 66899-02-3
4,4-dimethylpyrrolidin-2-one

: 898552-53-9
1-{4-[2-(4-chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyryl}-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride; water / 20 h / 120 °C

2: ethanol / 16 h / 85 °C / Heating / reflux

3: sodium hydrogencarbonate / chloroform; water / pH 7.1 - 7.4

4: potassium carbonate / 6 h / 120 °C

5: trifluoroacetic acid / water / 16 h / 90 °C

6: dmap; triethylamine / dichloromethane / 16 h / 25 °C

7: triethylamine / chloroform; acetonitrile / 16 h

With hydrogenchloride; dmap; water; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; chloroform; water; acetonitrile;

Reference yield:

: 898552-72-2
ethyl 3,3-dimethyl-4-aminobutanoate hydrochloride

: 898552-53-9
1-{4-[2-(4-chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyryl}-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / chloroform; water / pH 7.1 - 7.4

2: potassium carbonate / 6 h / 120 °C

3: trifluoroacetic acid / water / 16 h / 90 °C

4: dmap; triethylamine / dichloromethane / 16 h / 25 °C

5: triethylamine / chloroform; acetonitrile / 16 h

With dmap; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; chloroform; water; acetonitrile;