N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)methanesulfonamide
CAS No.:1548116-45-5
Molecular Formula:C₁₆H₂₄N₄O₄S
Molecular Weight:368.457
Hs Code.:

Synonyms:N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)methanesulfonamide

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Chemical Property of N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)methanesulfonamide

Chemical Property:

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Technology Process of N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)methanesulfonamide

There total 5 articles about N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353553-19-1
(4-(4-aminophenyl)piperazin-1-yl)(morpholino)methanone

: 124-63-0
methanesulfonyl chloride

: 1548116-45-5
N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)methanesulfonamide

Guidance literature:: With pyridine; at 20 ℃; for 0.25h;
DOI:10.1016/j.bmc.2013.12.050

Reference yield:

: 332943-12-1
morpholino(4-(4-nitrophenyl)piperazin-1-yl)methanone

: 1548116-45-5
N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran / 1 h / 2068.65 Torr

2: pyridine / 0.25 h / 20 °C

With pyridine; 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran;
DOI:10.1016/j.bmc.2013.12.050

Reference yield:

: 163587-60-8
4-(4-morpholinylcarbonyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

: 1548116-45-5
N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate / toluene / 16 h / Inert atmosphere

3: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran / 1 h / 2068.65 Torr

4: pyridine / 0.25 h / 20 °C

With pyridine; 5%-palladium/activated carbon; hydrogen; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmc.2013.12.050