(6-chloro-5-isopropylpyridazin-3-yl)[2,6-dibromo-4-(tetrahydropyran-2-yloxymethyl)phenyl]acetonitrile

Base Information

Chemical Name:(6-chloro-5-isopropylpyridazin-3-yl)[2,6-dibromo-4-(tetrahydropyran-2-yloxymethyl)phenyl]acetonitrile
CAS No.:920509-62-2
Molecular Formula:C₂₁H₂₂Br₂ClN₃O₂
Molecular Weight:543.686
Hs Code.:

Synonyms:(6-chloro-5-isopropylpyridazin-3-yl)[2,6-dibromo-4-(tetrahydropyran-2-yloxymethyl)phenyl]acetonitrile

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Chemical Property of (6-chloro-5-isopropylpyridazin-3-yl)[2,6-dibromo-4-(tetrahydropyran-2-yloxymethyl)phenyl]acetonitrile

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Technology Process of (6-chloro-5-isopropylpyridazin-3-yl)[2,6-dibromo-4-(tetrahydropyran-2-yloxymethyl)phenyl]acetonitrile

There total 6 articles about (6-chloro-5-isopropylpyridazin-3-yl)[2,6-dibromo-4-(tetrahydropyran-2-yloxymethyl)phenyl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 107228-51-3
3,6-dichloro-4-isopropyl-1,2-dihydropyridazine

: 920509-62-2
(6-chloro-5-isopropylpyridazin-3-yl)[2,6-dibromo-4-(tetrahydropyran-2-yloxymethyl)phenyl]acetonitrile

Guidance literature:: [2,6-dibromo-4-(tetrahydropyran-2-yloxymethyl)phenyl]acetonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 0.166667h;

3,6-dichloro-4-isopropyl-1,2-dihydropyridazine; In N,N-dimethyl-formamide; at 90 ℃; for 1h;

Reference yield: 65.0%

: 107228-51-3
3,6-dichloro-4-isopropyl-1,2-dihydropyridazine

: 920509-61-1
[2,6-dibromo-4-(tetrahydropyran-2-yloxymethyl)phenyl]acetonitrile

: 920509-62-2
(6-chloro-5-isopropylpyridazin-3-yl)[2,6-dibromo-4-(tetrahydropyran-2-yloxymethyl)phenyl]acetonitrile

Guidance literature:: [2,6-dibromo-4-(tetrahydropyran-2-yloxymethyl)phenyl]acetonitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 25 ℃; for 0.166667h; Inert atmosphere;

3,6-dichloro-4-isopropyl-1,2-dihydropyridazine; In N,N-dimethyl-formamide; mineral oil; at 90 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm4019299

Reference yield:

: 74896-66-5
Methyl 3,5-Dibromo-4-methylbenzoate

: 920509-62-2
(6-chloro-5-isopropylpyridazin-3-yl)[2,6-dibromo-4-(tetrahydropyran-2-yloxymethyl)phenyl]acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 24 °C / Reflux; Inert atmosphere

2.1: diisobutylaluminium hydride / water; tetrahydrofuran / 2.5 h / 0 °C

3.1: sulfuric acid / dimethyl sulfoxide / 1.5 h / 20 - 50 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 25 °C / Inert atmosphere

5.2: 1 h / 90 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm4019299