2-[6-(3-chlorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

Base Information

Chemical Name:2-[6-(3-chlorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt
CAS No.:1192312-82-5
Molecular Formula:C₂₅H₃₂ClN₅O₃*ClH
Molecular Weight:522.475
Hs Code.:

Synonyms:2-[6-(3-chlorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

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Chemical Property of 2-[6-(3-chlorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

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Technology Process of 2-[6-(3-chlorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

There total 8 articles about 2-[6-(3-chlorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192312-81-4
2-[6-(3-chlorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

: 1192312-82-5
2-[6-(3-chlorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 1192313-23-7
3-{[6-(3-chlorophenyl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl]oxy}propyl acetate

: 1192312-82-5
2-[6-(3-chlorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 0 - 70 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

3.1: 2-(Dimethylamino)pyridine; triethylamine / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C

5.1: hydrogenchloride / diethyl ether; dichloromethane

With hydrogenchloride; 2-(Dimethylamino)pyridine; water; sodium hydride; potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1192313-24-8
3-[(6-(3-chlorophenyl)-5-{2-[(1-methylethyl)amino]-2-oxoethyl}-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl)oxy]propyl acetate

: 1192312-82-5
2-[6-(3-chlorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

Guidance literature:: Multi-step reaction with 4 steps

1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

2: 2-(Dimethylamino)pyridine; triethylamine / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 - 65 °C

4: hydrogenchloride / diethyl ether; dichloromethane

With hydrogenchloride; 2-(Dimethylamino)pyridine; water; potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;