3-[(6-(3-chlorophenyl)-5-{2-[(1-methylethyl)amino]-2-oxoethyl}-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl)oxy]propyl acetate

Base Information

• Chemical Name: 3-[(6-(3-chlorophenyl)-5-{2-[(1-methylethyl)amino]-2-oxoethyl}-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl)oxy]propyl acetate
• CAS No.: 1192313-24-8
• Molecular Formula: C₂₂H₂₅ClN₄O₅
• Molecular Weight: 460.917
• Mol file: 1192313-24-8.mol

Synonyms:3-[(6-(3-chlorophenyl)-5-{2-[(1-methylethyl)amino]-2-oxoethyl}-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl)oxy]propyl acetate

Chemical Property of 3-[(6-(3-chlorophenyl)-5-{2-[(1-methylethyl)amino]-2-oxoethyl}-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl)oxy]propyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(6-(3-chlorophenyl)-5-{2-[(1-methylethyl)amino]-2-oxoethyl}-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl)oxy]propyl acetate

There total 5 articles about 3-[(6-(3-chlorophenyl)-5-{2-[(1-methylethyl)amino]-2-oxoethyl}-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl)oxy]propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-N-isopropylacetamide (2895-21-8) + 3-{[6-(3-chlorophenyl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl]oxy}propyl acetate (1192313-23-7) → 3-[(6-(3-chlorophenyl)-5-{2-[(1-methylethyl)amino]-2-oxoethyl}-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl)oxy]propyl acetate (1192313-24-8) + 3-{[6-(3-chlorophenyl)-4-({2-[(1-methylethyl)amino]-2-oxoethyl}oxy)pyrazolo[1,5-a]pyrazin-2-yl]oxy}propyl acetate (1192313-25-9)

Guidance literature:

3-{[6-(3-chlorophenyl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl]oxy}propyl acetate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

2-chloro-N-isopropylacetamide; With sodium iodide; In N,N-dimethyl-formamide; at 0 - 70 ℃;

Reference yield:

2-chloro-N-isopropylacetamide (2895-21-8) + 3-{[6-(3-chlorophenyl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl]oxy}propyl acetate (1192313-23-7) → 3-[(6-(3-chlorophenyl)-5-{2-[(1-methylethyl)amino]-2-oxoethyl}-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl)oxy]propyl acetate (1192313-24-8)

Guidance literature:

3-{[6-(3-chlorophenyl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl]oxy}propyl acetate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

2-chloro-N-isopropylacetamide; With sodium iodide; In N,N-dimethyl-formamide; at 0 - 70 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.07.037

Reference yield:

ethyl 3-[(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)oxy]-1H-pyrazole-5-carboxylate (1192313-21-5) → 3-[(6-(3-chlorophenyl)-5-{2-[(1-methylethyl)amino]-2-oxoethyl}-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl)oxy]propyl acetate (1192313-24-8) + 3-{[6-(3-chlorophenyl)-4-({2-[(1-methylethyl)amino]-2-oxoethyl}oxy)pyrazolo[1,5-a]pyrazin-2-yl]oxy}propyl acetate (1192313-25-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 20 - 60 °C

2.1: 24 h / 100 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 0 - 70 °C

With sodium hydride; sodium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

2-chloro-N-isopropylacetamide

3-{[6-(3-chlorophenyl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl]oxy}propyl acetate

ethyl 3-[(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)oxy]-1H-pyrazole-5-carboxylate

ethyl 1-[2-(3-chlorophenyl)-2-oxoethyl]-3-[(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)oxy]-1H-pyrazole-5-carboxylate

Downstream raw materials:

2-({6-(3-chlorophenyl)-2-[(3-hydroxypropyl)oxy]pyrazolo[1,5-a]pyrazin-4-yl}oxy)-N-(1-methylethyl)acetamide

2-[6-(3-chlorophenyl)-2-[(3-hydroxypropyl)oxy]-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

2-[6-(3-chlorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

2-[6-(3-chlorophenyl)-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt