5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylic acid

Base Information

Chemical Name:5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylic acid
CAS No.:152775-54-7
Molecular Formula:C₁₇H₁₉N₅O₄
Molecular Weight:357.369
Hs Code.:

Synonyms:5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylic acid

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Chemical Property of 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylic acid

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Technology Process of 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylic acid

There total 8 articles about 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.3%

: 152775-84-3
ethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylate

: 152775-54-7
5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylic acid

Guidance literature:: With lithium hydroxide; water; In ethanol; a) RT, 12 h, b) reflux, 2 h;
DOI:10.1021/jm00074a004

Reference yield:

: 5390-04-5
pent-1-yn-5-ol

: 152775-54-7
5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / Ph₃P, DEAD / CH₂Cl₂ / 12 h

2: 37.5 percent / triethylamine / CHCl₃ / 18 h / Heating

3: 72.3 percent / LiOH, H₂O / ethanol / a) RT, 12 h, b) reflux, 2 h

With lithium hydroxide; water; triethylamine; triphenylphosphine; diethylazodicarboxylate; In ethanol; dichloromethane; chloroform;
DOI:10.1021/jm00074a004

Reference yield:

: 4198-90-7
3,5-dimethyl-4-hydroxybenzonitrile

: 152775-54-7
5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 93.2 percent / K₂CO₃ / acetone / 18 h / Heating

2: 62 percent / NaN₃, NH₄Cl / dimethylformamide / 24 h / 110 °C

3: 67 percent / K₂CO₃ / acetonitrile / 1 h / Heating

4: 96 percent / BBr₃ / CH₂Cl₂

5: 84 percent / Ph₃P, DEAD / CH₂Cl₂ / 12 h

6: 37.5 percent / triethylamine / CHCl₃ / 18 h / Heating

7: 72.3 percent / LiOH, H₂O / ethanol / a) RT, 12 h, b) reflux, 2 h

With lithium hydroxide; sodium azide; water; boron tribromide; potassium carbonate; ammonium chloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm00074a004